Proliferación linfoide indolente cutánea CD8 positiva a propósito de tres casos con compromiso facial

Autores/as

  • Rafael Parra-Medina Instituto Nacional de Cancerología
  • Natalia Olaya Instituto Nacional de Cancerología
  • Nicolás Villamizar-Rivera Instituto Nacional de Cancerología
  • Samuel D. Morales Instituto Nacional de Cancerología

DOI:

https://doi.org/10.35509/01239015.215

Palabras clave:

Linfoma T, CD8 , Proliferación indolente, Reordenamientos, TCR, Latinoamérica

Resumen

La proliferación linfoide indolente cutánea CD8 positiva es una variante recientemente descrita de linfoma T cutáneo que se caracteriza por un nódulo, pápula o placa eritematosa de crecimiento lento que puede afectar la región facial o extrafacial. En el estudio de patología se caracteriza por un infiltrado monomorfo de linfocitos T a lo largo de la dermis con presencia de zona de Grenz y ausencia de epidermotropismo. El infiltrado es característicamente CD8+ así como CD3+, TIA-1+, CD4-, CD56- CD30-, PD-1-, Granzima B- y EBER negativo.
El índice de proliferación Ki-67 es inferior al 10% y se observan reordenamientos clonales de los genes del receptor de antígeno de la célula T, TCR. El seguimiento clínico es favorable y no se ha observado compromiso sistémico. Se presentan tres casos con compromiso facial (dos casos en pabellón auricular y un caso con compromiso nasal), con presentación clínica y hallazgos histopatológicos típicos (curiosamente un caso con cambio de célula clara), y además se realizaron estudios de clonalidad.

Biografía del autor/a

Rafael Parra-Medina, Instituto Nacional de Cancerología

Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C, Colombia

Natalia Olaya, Instituto Nacional de Cancerología

Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C, Colombia

Nicolás Villamizar-Rivera, Instituto Nacional de Cancerología

Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C, Colombia

Samuel D. Morales, Instituto Nacional de Cancerología

Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, Colombia

Referencias bibliográficas

Petrella T, Maubec E, Cornillet-Lefebvre P, Willemze R, Pluot M, Durlach A, et al. Indolent CD8-positive lymphoid proliferation of the ear: a distinct primary cutaneous T-cell lymphoma? Am J Surg Pathol. 2007;31:1887-92.

https://doi.org/10.1097/PAS.0b013e318068b527

Li XQ, Zhou XY, Sheng WQ, Xu YX, Zhu XZ. Indolent CD8+ lymphoid proliferation of the ear: A new entity and possible occurrence of signet ring cells: Correspondence. Histopathology. 2009;55:468-70.

https://doi.org/10.1111/j.1365-2559.2009.03383.x

Beltraminelli H, Müllegger R, Cerroni L. Indolent CD8+ lymphoid proliferation of the ear: A phenotypic variant of the small-medium pleomorphic cutaneous T-cell lymphoma? J Cutan Pathol. 2010;37:81-4.

https://doi.org/10.1111/j.1600-0560.2009.01278.x

Suchak R, O'Connor S, McNamara C, Robson A. Indolent CD8-positive lymphoid proliferation on the face: Part of the spectrum of primary cutaneous small-/medium-sized pleomorphic T-cell lymphoma or a distinct entity? J Cutan Pathol. 2010;37:977-81.

https://doi.org/10.1111/j.1600-0560.2009.01448.x

Ryan AJ, Robson A, Hayes BD, Sheahan K, Collins P. Primary cutaneous peripheral T-cell lymphoma, unspecified with an indolent clinical course: A distinct peripheral T-cell lymphoma? Clin Exp Dermatol. 2010;35:892-6.

https://doi.org/10.1111/j.1365-2230.2010.03849.x

Swick BL, Baum CL, Venkat AP, Liu V. Indolent CD8+ lymphoid proliferation of the ear: Report of two cases and review of the literature. J Cutan Pathol. 2011;38:209-15.

https://doi.org/10.1111/j.1600-0560.2010.01647.x

Géraud C, Goerdt S, Klemke CD. Primary cutaneous CD8+ small/medium-sized pleomorphic T-cell lymphoma, ear-type: A unique cutaneous T-cell lymphoma with a favourable prognosis. Br J Dermatol. 2011;164:456-8.

https://doi.org/10.1111/j.1365-2133.2010.10105.x

Kempf W, Kazakov DV, Cozzio A, Kamarashev J, Kerl K, Plaza T, et al. Primary Cutaneous CD8+ Small- to Medium-Sized Lymphoproliferative Disorder in Extrafacial Sites. Am J Dermatopathol. 2013;35:159-66.

https://doi.org/10.1097/DAD.0b013e31825c3a33

Butsch F, Kind P, Bräuninger W. Bilateral indolent epidermotropic CD8-positive lymphoid proliferations of the ear. J Dtsch Dermatol Ges. 2012;8:195-6.

https://doi.org/10.1111/j.1610-0387.2011.07859.x

Zeng W, Nava VE, Cohen P, Ozdemirli M. Indolent CD8-positive T-cell lymphoid proliferation of the ear: A report of two cases. J Cutan Pathol. 2012;39:696-700.

https://doi.org/10.1111/j.1600-0560.2012.01917.x

Valois A, Bastien C, Granel-Broca F, Cuny J-F, Barbaud A, Schmutz J-L. [Indolent lymphoma of the ear]. Ann dermatologie vénéréologie. 2012;139:818-23.

https://doi.org/10.1016/j.annder.2012.10.578

Milley S, Bories N, Balme B, Thomas L, Dalle S. [Indolent CD8+ lymphoid proliferation on the nose]. Ann dermatologie vénéréologie. 2012;139:812-7.

https://doi.org/10.1016/j.annder.2012.09.012

Wobser M, Petrella T, Kneitz H, Kerstan A, Goebeler M, Rosenwald A, et al. Extrafacial indolent CD8-positive cutaneous lymphoid proliferation with unusual symmetrical presentation involving both feet. J Cutan Pathol. 2013;40:955-61.

https://doi.org/10.1111/cup.12213

Greenblatt D, Ally M, Child F, Scarisbrick J, Whittaker S, Morris S, et al. Indolent CD8+ lymphoid proliferation of acral sites: A clinicopathologic study of six patients with some atypical features. J Cutan Pathol. 2013;40:248-58.

https://doi.org/10.1111/cup.12045

Hagen JW, Magro CM. Indolent CD8+ lymphoid proliferation of the face with eyelid involvement. Am J Dermatopathol. 2014;36:137-41.

https://doi.org/10.1097/DAD.0b013e318297f7fd

Li JY, Guitart J, Pulitzer MP, Subtil A, Sundram U, Kim Y, et al. Multicenter Case Series of Indolent Small/Medium-Sized CD8 + Lymphoid Proliferations With Predilection for the Ear and Face. Am J Dermatopathol. 2014;36:402-8.

https://doi.org/10.1097/DAD.0b013e3182a74c7a

Wobser M, Roth S, Reinartz T, Rosenwald A, Goebeler M, Geissinger E. CD68 expression is a discriminative feature of indolent cutaneous CD8-positive lymphoid proliferation and distinguishes this lymphoma subtype from other CD8-positive cutaneous lymphomas. Br J Dermatol. 2015;172:1573-80.

https://doi.org/10.1111/bjd.13628

Kluk J, Kai A, Koch D, Taibjee SM, O'Connor S, Persic M, et al. Indolent CD8-positive lymphoid proliferation of acral sites: three further cases of a rare entity and an update on a unique patient. J Cutan Pathol. 2015:8 [Epub ahead of print].

https://doi.org/10.1111/cup.12633

Vaillant L, Monégier du Sorbier C, Arbeille B, de Muret A, Lorette G. Cutaneous T cell lymphoma of signet ring cell type: a specific clinico-pathologic entity. Acta Derm Venereol. 1993;73: 255-8.

Friedmann D, Wechsler J, Delfau MH, Estève E, Farcet JP, de Muret A, et al. Primary cutaneous pleomorphic small T-cell lymphoma. A review of 11 cases. The French Study Group on Cutaneous Lymphomas. Arch Dermatol. 1995;131:1009-15.

https://doi.org/10.1001/archderm.1995.01690210039007

Fika Z, Karkos PD, Badran K, Williams RE. Primary cutaneous aggressive epidermotropic CD8 positive cytotoxic T-cell lymphoma of the ear. J Laryngol Otol. 2007;121:503-5.

https://doi.org/10.1017/S0022215106005457

Khamaysi Z, Ben-Arieh Y, Epelbaum R, Bergman R. Pleomorphic CD8+ small/medium size cutaneous T-cell lymphoma. Am J Dermatopathol. 2006;28:434-7.

https://doi.org/10.1097/01.dad.0000210389.36724.dd

Eich D, Eich HT, Otte HG, Ghilescu V, Stadler R. [Photodynamic therapy of cutaneous T-cell lymphoma at special sites]. Der Hautarzt; Zeitschrift f¨ur Dermatologie, Venerol und verwandte Gebiete. 1999;50:109-14.

https://doi.org/10.1007/s001050050873

van Dongen JJM, Langerak AW, Brüggemann M, Evans PAS, Hummel M, Lavender FL, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257-317.

https://doi.org/10.1038/sj.leu.2403202

Xue Y, Wang Q, He X. Clear cell variant of diffuse large B-cell lymphoma: a case report and review of the literature. Int J Clin Exp Pathol. 2015;8:7594-9.

Hartmann S, Helling A, Döring C, Renné C, Hansmann M-L. Clonality testing of malignant lymphomas with the BIOMED-2 primers in a large cohort of 1969 primary and consultant biopsies. Pathol Res Pract. 2013;209:495-502.

https://doi.org/10.1016/j.prp.2013.05.004

Grogg KL, Jung S, Erickson LA, McClure RF, Dogan A. Primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma: a clonal T-cell lymphoproliferative disorder with indolent behavior. Mod Pathol. 2008;21:708-15.

https://doi.org/10.1038/modpathol.2008.40

Leinweber B, Beltraminelli H, Kerl H, Cerroni L. Solitary small- to medium-sized pleomorphic T-cell nodules of undetermined significance: clinical, histopathological, immunohistochemical and molecular analysis of 26 cases. Dermatology. 2009;219:42-7.

https://doi.org/10.1159/000212118

Bachelez H, Hadida F, Parizot C, Flageul B, Kemula M, Dubertret L, et al. Oligoclonal expansion of HIV-specific cytotoxic CD8 T lymphocytes in the skin of HIV-1-infected patients with cutaneous pseudolymphoma. J Clin Invest. 1998;101:2506-16.

https://doi.org/10.1172/JCI1450

El-Shabrawi-Caelen L, Cerroni L, Medeiros LJ, McCalmont TH. Hypopigmented mycosis fungoides: frequent expression of a CD8+ T-cell phenotype. Am J Surg Pathol. 2002;26:450-7.

https://doi.org/10.1097/00000478-200204000-00006

Lu D, Patel KA, Duvic M, Jones D. Clinical and pathological spectrum of CD8-positive cutaneous T-cell lymphomas. J Cutan Pathol. 2002;29:465-72.

https://doi.org/10.1034/j.1600-0560.2002.290804.x

Cómo citar

[1]
Parra-Medina, R. , Olaya, N. , Villamizar-Rivera, N. y Morales, S.D. 2017. Proliferación linfoide indolente cutánea CD8 positiva a propósito de tres casos con compromiso facial. Revista Colombiana de Cancerología. 21, 1 (mar. 2017), 38–43. DOI:https://doi.org/10.35509/01239015.215.

Descargas

Los datos de descargas todavía no están disponibles.

Descargas

Publicado

2017-03-01

Número

Sección

Reportes de caso