Proliferación linfoide indolente cutánea CD8 positiva a propósito de tres casos con compromiso facial

Autores/as

  • Rafael Parra-Medina Instituto Nacional de Cancerología
  • Natalia Olaya Instituto Nacional de Cancerología
  • Nicolás Villamizar-Rivera Instituto Nacional de Cancerología
  • Samuel D. Morales Instituto Nacional de Cancerología

DOI:

https://doi.org/10.35509/01239015.215

Palabras clave:

Linfoma T, CD8 , Proliferación indolente, Reordenamientos, TCR, Latinoamérica

Resumen

La proliferación linfoide indolente cutánea CD8 positiva es una variante recientemente descrita de linfoma T cutáneo que se caracteriza por un nódulo, pápula o placa eritematosa de crecimiento lento que puede afectar la región facial o extrafacial. En el estudio de patología se caracteriza por un infiltrado monomorfo de linfocitos T a lo largo de la dermis con presencia de zona de Grenz y ausencia de epidermotropismo. El infiltrado es característicamente CD8+ así como CD3+, TIA-1+, CD4-, CD56- CD30-, PD-1-, Granzima B- y EBER negativo.
El índice de proliferación Ki-67 es inferior al 10% y se observan reordenamientos clonales de los genes del receptor de antígeno de la célula T, TCR. El seguimiento clínico es favorable y no se ha observado compromiso sistémico. Se presentan tres casos con compromiso facial (dos casos en pabellón auricular y un caso con compromiso nasal), con presentación clínica y hallazgos histopatológicos típicos (curiosamente un caso con cambio de célula clara), y además se realizaron estudios de clonalidad.

Biografía del autor/a

Rafael Parra-Medina, Instituto Nacional de Cancerología

Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C, Colombia

Natalia Olaya, Instituto Nacional de Cancerología

Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C, Colombia

Nicolás Villamizar-Rivera, Instituto Nacional de Cancerología

Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C, Colombia

Samuel D. Morales, Instituto Nacional de Cancerología

Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, Colombia

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Cómo citar

[1]
Parra-Medina, R. et al. 2017. Proliferación linfoide indolente cutánea CD8 positiva a propósito de tres casos con compromiso facial. Revista Colombiana de Cancerología. 21, 1 (mar. 2017), 38–43. DOI:https://doi.org/10.35509/01239015.215.

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01-03-2017

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