Key points in body cavity cytology
DOI:
https://doi.org/10.35509/01239015.848Keywords:
cytology, body fluids, mesothelial cells, carcinomas, lymphomasAbstract
Cytology plays a fundamental role in the timely diagnosis and treatment of benign and malignant diseases. Reported rates of malignancy in effusions range from 15% to 50%. About 95% of them represent metastatic disease, consisting primarily of adenocarcinomas (70-77%). Mesothelial cells appear alone in most cases, but they may be in groups showing morphological patterns suggestive of malignancy. The pronounced reactivity of mesothelial cells can mimic a malignant process; therefore, caution when diagnosing and the use of ancillary techniques such as immunocytochemistry is suggested to resolve these diagnostic challenges and increase the sensitivity and specificity of body cavity cytology. This article aims to provide a practical approach to evaluate body fluid cytology samples, emphasizing cytomorphological characteristics that allow establishing a definitive diagnosis or a presumptive one that will require the help of complementary techniques such as immunocytochemistry.
Author Biographies
Mónica García-Buitrago , Departamento de Citopatología, Universidad de Miami, Miami, Estados Unidos.
1. Departamento de Citopatología, Universidad de Miami, Miami, Estados Unidos.
Rafael Parra-Medina, Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Bogotá, D.C., Colombia.
2. Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Bogotá, D.C., Colombia.
3. Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
Ana Piedrahita, Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Bogotá, D.C., Colombia.
2. Departamento de Patología, Fundación Universitaria de Ciencias de la Salud, Bogotá, D.C., Colombia.
3. Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
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