Etiology of pulmonary nodules in patients with breast cancer
DOI:
https://doi.org/10.35509/01239015.81Keywords:
nódulo pulmonar solitario; nódulos pulmonares múltiples; metástasis de la neoplasia; neoplasias de la mama., solitary pulmonary nodule; multiple pulmonary nodule; neoplasm metastasis; breast neoplasms.Abstract
Materials and Methods: A case-series study was developed to describe the clinical, histological and anatomopathological characteristics of a sample of patients with a diagnosis of de novo metastatic breast cancer or whom presented with pulmonary nodules during their disease that required surgical resection by wedge pulmonary or lobectomy in the INC, between January 1, 2015 and April 30, 2018.
Results: Fifty-five cases were included in the study period, of which 26 (47.3%) were breast cancer metastases, 9 (16.4%) were pulmonary primary second, and 1 (1.8%) patient had primary pulmonary cancer and one breast metastasis concomitantly. Another 2 (3.6%) patients had metastases from other organs, one from the rectum and one from the thyroid, while the remaining 17 (30.9%) patients presented a report of benign pulmonary lesions in the pathological anatomy.
Conclusion: The presence of pulmonary nodules in patients with breast cancer are not always secondary to metastatic disease. Other etiologies may exist, such as primary pulmonary cancer, metastasis from other cancers, benign lung tumors or infections. Knowing the etiology of pulmonary nodules in patients with breast cancer is crucial to evaluate the therapeutic options .
References
Bray F, Ferlay J, Soerjomataram I. Global Cancer Statistics 2018: GLOBOCAN estimates of Incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. https://doi.org/10.3322/caac.21492
Instituto Nacional de Cancerlogía.Tabla 21. Casos nuevos de cáncer de mama en pacientes residentes en Bogotá, según estado clínico al Ingreso y régimen de afiliación, INC, Colombia, 2015. En: Anuario Estadístico 2015. Bogotá: Instituto Nacional de Cancerlogía; 2018. p. 59.
Chikarmane SA, Tirumani SH, Howard SA, Jagannathan JP, Dipiro PJ. Metastatic patterns of breast cancer subtypes: what radiologists should know in the era of personalized cancer medicine. Clin Radiol. 2015;70(1):1-10. https://doi.org/10.1016/j.crad.2014.08.015
Caparica R, Pérez Mak M, Rocha CH, Isaacsson-Velho PH, Viana P, Moura MRL, et al. Pulmonary Nodules in Patients With Nonpulmonary Cancer : Not Always Metastases. J Glob Oncol. 2016;2(3):138-44. https://doi.org/10.1200/JGO.2015.002089
Welter S, Jacobs J, Krbek T, Tötsch M, Stamatis G. Pulmonary metastases of breast cancer. When is resection indicated? Eur J Cardiothorac Surg. 2008;34(6):1228-34. ttps://doi.org/10.1016/j.ejcts.2008.07.063
Matsuura K, Itamoto T, Noma M, Ohara M, Akimoto E. Significance of lung biopsy for the definitive diagnosis of lung nodules in breast cancer patients. 2018;8(2):250-6. https://doi.org/10.3892/mco.2017.1511
Barjaktarevic I, Arenberg D, Grimes BS, Ruchalski K, Aberle DR. Indeterminate Pulmonary Nodules: How to Minimize Harm. Semin Respir Crit Care Med. 2016;37(5):689-707. https://doi.org/10.1055/s-0036-1592187
Pockaj BA, Wasif N, Dueck AC, Wigle DA, Boughey JC, Degnim AC, et al. Metastasectomy and surgical resection of the primary tumor in patients with stage IV breast cancer: time for a second look? Ann Surg Oncol. 2010;17(9):2419-26. https://doi.org/10.1245/s10434-010-1016-1
Fan J, Chen D, Du H, Shen C, Che G. Prognostic factors for resection of isolated pulmonary metastases in breast cancer patients: a systematic review and meta-analysis. J Thorac Dis. 2015;7(8):1441-51.
Rena O, Papalia E, Ruffini E, Filosso PL, Oliaro A, Maggi G, et al. The role of surgery in the management of solitary pulmonary nodule in breast cancer patients. Eur J Surg Oncol. 2007;33(5):546-50. https://doi.org/10.1016/j.ejso.2006.12.015
Goldstraw P, Chansky K, Crowley J, Rami-porta R, Asamura H, Eberhardt WE, et al. The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming ( Eighth ) Edition of the TNM Classi fi cation for Lung Cancer. J Thorac Oncol. 2016;11(1):39-51. https://doi.org/10.1016/j.jtho.2015.09.009
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