Palliative cryosurgery for mucosous melanoma in covid-19 pandemic

Authors

DOI:

https://doi.org/10.35509/01239015.804

Keywords:

mucosal melanoma, cryosurgery, palliative care, immunomodulation

Abstract

Primary melanomas in the oral mucosa arise from the malignant proliferation of melanocytes. They rarely occur, with aggressive behavior and poor prognosis. We present the case of an 82-year-old patient with oral mucous melanoma with metastatic involvement of the right cervical lymph node, multisegmental lung metastases, at the gastroesophageal junction and at the level of the L3 vertebral body with extension to the dural sac, without response to radiotherapy, chemotherapy or immunotherapy. The patient undergoes palliative cryosurgery of the primary tumor every two to three weeks, observing a notable decrease of the tumoral lesion when the procedure is performed, with recovery of oral functionality and a decrease in the size of lymph node metastases in the neck. We present the technique used in the context of the COVID-19 pandemic, the benefits of cryosurgery, its mechanism of action and its immunomodulatory function, and the future benefit of its combination with immunotherapy for primary management of advanced melanomas.

References

Botello-Mojica HM, Insuasty-Moreno AP, Jaramillo-Ayerbe F. Caracterización del melanoma maligno en la Clínica de Tumores de Piel y Mucosas, Universidad de Caldas, 2005-2015. Rev la Asoc Colomb Dermatología y Cirugía Dermatológica. 2017 Oct;25(4):276–83. https://doi.org/10.29176/2590843X.301

Osorio M, Moubayed SP, Hernandez-Prera J, Scott JC, Urken ML. Primary mucosal melanoma of the palatine tonsil: Report of a case and review of the literature. Am J Otolaryngol - Head Neck Med Surg. 2017 Jul;38(4):501–4. https://doi.org/10.1016/j.amjoto.2017.04.010

Lõpez F, Rodrigo JP, Cardesa A, Triantafyllou A, Devaney KO, Mendenhall WM, et al. Update on primary head and neck mucosal melanoma. Head Neck. 2016 Jan;38(1):147–55. https://doi.org/10.1002/hed.23872

Dominiak NR, Wick MR, Smith MT. Mucosal melanomas: Sitespecific information, comparisons with cutaneous tumors, and differential diagnosis. Semin Diagn Pathol. 2016 Jul;33(4):191–7. https://doi.org/10.1053/j.semdp.2016.04.003

López Chagín A. Estudio epidemiológico del melanoma maligno de la cavidad bucal en hospitales de referencia nacional de Caracas, Venezuela: 1959-2002. Acta odontol venez. 2007;22–8. Disponible en: <http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0001-63652007000100004&lng=es&nrm=iso>. ISSN 0001-6365.

Deyhimi P, Razavi SM, Shahnaseri S, Khalesi S, Homayoni S, Tavakoli P. Rare and Extensive Malignant Melanoma of the Oral Cavity: Report of Two Cases. J Dent (Shiraz, Iran). 2017 Sep;18(3):227–33. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29034279/

Cala Anahí C, Flores Elizabeth C, Daniela Ortiz S. TECNICAS DE ANESTESIA TRONCULAR DEL MAXILAR INFERIOR. Rev Act Clin Med . 2012;27:1329–33. Disponible en: http://www.revistasbolivianas.ciencia.bo/scielo.php?script=sci_abstract&pid=S2304-37682012001200006&lng=es&nrm=iso&tlng=es

Recomendaciones para minimizar el riesgo de contagio del COVID-19 al retornar a la consulta externa de dermatología -CENTRO DERMATOLOGICO - Federico Lleras Acosta. Disponible en: https://www.dermatologia.gov.co/atencion-serviciociudadania/prevencion-covid-19

Johnson E, Neumann M, Lepoudre C. Mucosal melanoma of the inferior turbinate: A case report and literature review. Otolaryngol Case Reports. 2020 Sep;16:100194. https://doi.org/10.1016/j.xocr.2020.100194

Manolidis S, Donald PJ. Malignant mucosal melanoma of the head and neck: review of the literature and report of 14 patients. Cancer. 1997 Oct 15;80(8):1373-86. https://doi.org/10.1002/(sici)1097-0142(19971015)80:8%3C1373::aid-cncr3%3E3.0.co;2-g

Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998 Oct 15;83(8):1664-78. https://doi.org/10.1002/(sici)1097-0142(19981015)83:8%3C1664::aid-cncr23%3E3.0.co;2-g

Mihajlovic M, Vlajkovic S, Jovanovic P, Stefanovic V. Primary mucosal melanomas: A comprehensive review. Vol. 5, International Journal of Clinical and Experimental Pathology. Int J Clin Exp Pathol; 2012. p. 739–53. Disponible en: https://pubmed.ncbi.nlm.nih.gov/23071856/

Goldemberg DC, Thuler LCS, de Melo AC. An Update on Mucosal Melanoma: Future Directions. Acta Dermatovenerol Croat. 2019 Mar;27(1):11–5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31032785/

Umeda M, Mishima Y, Teranobu O, Nakanishi K, Shimada K. Heterogeneity of primary malignant melanomas in oral mucosa: An analysis of 43 cases in Japan. Pathology. 1988 Jan;20(3):234–41. https://doi.org/10.3109/00313028809059498

Lourenço S V., Fernandes JD, Hsieh R, Coutinho-Camillo CM, Bologna S, Sangueza M, et al. Head and neck mucosal melanoma: A review. Vol. 36, American Journal of Dermatopathology. Lippincott Williams and Wilkins; 2014. p.578–87. https://doi.org/10.1097/dad.0000000000000035

Mackintosh JA. The antimicrobial properties of melanocytes, melanosomes and melanin and the evolution of black skin. J Theor Biol. 2001 Jul;211(2):101–13. Disponible en: https://doi.org/10.1006/jtbi.2001.2331

Ascierto PA, Accorona R, Botti G, Farina D, Fossati P, Gatta G, et al. Mucosal melanoma of the head and neck. Vol.112, Critical Reviews in Oncology/Hematology. Elsevier Ireland Ltd; 2017. p. 136–52. https://doi.org/10.1016/j.critrevonc.2017.01.019

Gorsky M, Epstein JB. Melanoma arising from the mucosal surfaces of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86(6):715–9. https://doi.org/10.1016/s1079-2104(98)90209-8

Chen M, Wu Y, Li W, Zhang X, Chen L, Zheng X, et al. Target sequencing identify loss of function variants in FSIP1 are associated with one particular subtype of mucosal melanoma. Gene. 2020 Jul;759:144964. https://doi.org/10.1016/j.gene.2020.144964

Loree TR, Mullins AP, Spellman J, North JH, Hicks WL. Head and neck mucosal melanoma: A 32-year review. Ear, Nose Throat J. 1999;78(5):372–5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/10355199/

Smith MH, Bhattacharyya I, Cohen DM, Islam NM, Fitzpatrick SG, Montague LJ, et al. Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics. Head Neck Pathol. 2016 Sep;10(3):298–305. https://doi.org/10.1007%2Fs12105-016-0693-x

Lin CW, Lee YP, Hwang MJ, Chiang CP. Oral mucosal melanoma: Case report. J Dent Sci. 2020 Dec;15(4):556-557. doi: 10.1016/j.jds.2020.06.011. Epub 2020 Jun 17.

Scala M, Gipponi M, Queirolo P, Mereu P, Solari N, Monteghirfo S, et al. Cryosurgery for advanced malignant melanoma of the facila skin. A case report. In Vivo (Brooklyn). 2006 Jan;20(1):153–6. https://doi.org/10.1016%2Fj.jds.2020.06.011

Tobón MX, Franco VE, Fierro E. Criocirugía. Rev la Asoc Colomb Dermatología y Cirugía Dermatológica. 2014 Oct;22(4):303–16. https://doi.org/10.29176/2590843X.267

Yakkala C, Chiang CLL, Kandalaft L, Denys A, Duran R. Cryoablation and immunotherapy: An enthralling synergy to confront the tumors. Vol. 10, Frontiers in Immunology. Frontiers Media S.A.; 2019. https://doi.org/10.3389/fimmu.2019.02283

Baust JG, Gage AA. Progress Toward Optimization of Cryosurgery. Vol. 3, Technology in Cancer Research and Treatment. Adenine Press; 2004. p. 95–101. https://doi.org/10.1177/153303460400300202

Pasquali P. The cryosurgery alternative. Int J Dermatol. 2007 May;46(5):511–3.

Joosten JJA, V. Muijen GNP, Wobbes T, Ruers TJM. In vivo destruction of tumor tissue by cryoablation can induce inhibition of secondary tumor growth: An experimental study. Cryobiology. 2001 Feb;42(1):49–58. https://doi.org/10.1006/cryo.2001.2302

Zhang J, Yu M, Li X, Huang X, Wang H. Combination therapy improves immune response and prognosis in patients with advanced oral mucosal melanoma: A clinical treatment success. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Oct;126(4):307–16. https://doi.org/10.1016/j.oooo.2018.05.004

Osada S, Imai H, Tomita H, Tokuyama Y, Okumura N, Matsuhashi N, et al. Serum cytokine levels in response to hepatic cryoablation. J Surg Oncol. 2007 May;95(6):491–8. https://doi.org/10.1002/jso.20712

Dendritic Cell Therapy After Cryosurgery in Combination With Pembrolizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Remove by Surgery - ClinicalTrials. gov. Disponible en: https://clinicaltrials.gov/ct2/show/NCT03325101

Cryotherapy With in Situ Immunotherapy in Melanoma Metastasis (CRIRIN)- ClinicalTrials.gov. Disponible en: https://clinicaltrials.gov/ct2/show/NCT03325101

Kim DW, Haymaker C, McQuail N, Sirmans E, Spencer C, Glitza I, et al. Pilot study of intratumoral (IT) cryoablation (cryo) in combination with systemic checkpoint blockade in patients with metastatic melanoma (MM). J Immunother Cancer. 2015 Dec;3(S2):P137. https://doi.org/10.1186%2F2051-1426-3-S2-P137

How to Cite

[1]
Botello Mojica, H.M. et al. 2022. Palliative cryosurgery for mucosous melanoma in covid-19 pandemic. Revista Colombiana de Cancerología. 26, 3 (Sep. 2022), 337–345. DOI:https://doi.org/10.35509/01239015.804.

Downloads

Download data is not yet available.

Published

2022-09-26

Issue

Section

Reportes de caso
Crossref Cited-by logo