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Clonal hematopoiesis of indeterminate potential (CHIP): Beyond a model of field cancerization

Authors

Oscar Andres Franco Tavera Departamento de Patología. Universidad Nacional de Colombia, Bogotá. Colombia
Natalia Olaya Morales

DOI:

Keywords:

clonal hematopoiesis, clonal expansion, field cancerization, chemotherapy, therapy-related myeloid neoplasm, somatic mutation, inflammation, aging

Abstract References How to Cite

Abstract

Clonal hematopoiesis of indeterminate potential, CHIP, is the expansion of hematopoietic stem cells harboring one of more somatic mutations. These patients do not have clinical hematologic neoplasia, myelodysplasia or dysplasia but can progress to a malignant process to a rate of 0.5 to 1% per year. CHIP could be used as a field cancerization model and it has been associated with chronic inflammatory disease, arteriosclerosis, diabetes and autoimmune conditions. CHIP is also considered a predictive factor in cancer patients receiving chemotherapy and radiotherapy.

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How to Cite

[1]

Franco Tavera, O.A. and Olaya Morales, N. 2022. Clonal hematopoiesis of indeterminate potential (CHIP): Beyond a model of field cancerization. Revista Colombiana de Cancerología. 25, 4 (Aug. 2022), 210–221. DOI:https://doi.org/10.35509/01239015.726.

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