Immunohistochemistry with monoclonal antibodies in peruvian indigenous with breast cancer, to forecast Global Survival

Authors

  • Renzo Reynaldo Gamarra Manrique Departamento de Oncología, Hospital Carlos Alberto Seguín Escobedo de ESSALUD, Perú
  • Marisol Tipula Mamani Laboratorio de Biología Molecular y Biotecnología, Universidad Nacional de San Agustín de Arequipa, Perú.
  • Durothy Lorenza Valdivia Díaz Laboratorio de Biología Molecular y Biotecnología, Universidad Nacional de San Agustín de Arequipa, Perú.

DOI:

https://doi.org/10.35509/01239015.719

Keywords:

breast cancer, Antibodies, Monoclonal, neoplasm Staging, HER2, immunohistochemistry

Abstract

Objective: To apply the monoclonal antibody technique for HER2/neu, in indigenous natives of Peru with breast cancer, as well as to correlate molecular overexpression with global survival.

Patients and methods: Experimental, prospective and analytical study. 23 biological samples from indigenous Andean patients from Arequipa, with a definitive diagnosis of breast adenocarcinoma, were evaluated. HER2/neu expression was determined by immunohistochemistry with monoclonal antibodies.

Results: 43,4% (10 cases) were positive for overexpression. Negative cases were 56,6% (13 cases). The overall survival at 3 years was 69.9% for the overexpressed HER2/neu and 84,6% for the negative ones, showing a statistically significant difference (p=0.017).

Conclusions: it is feasible to apply the immunohistochemistry technique in Andean Indians with breast cancer. Likewise, there was a correlation between HER2/neu receptor overexpression with lower overall survival. The main benefit of this technique is to justify the use of biological therapy with monoclonal antibodies, according to the molecular profile.

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How to Cite

[1]
Gamarra Manrique, R.R. et al. 2021. Immunohistochemistry with monoclonal antibodies in peruvian indigenous with breast cancer, to forecast Global Survival. Revista Colombiana de Cancerología. 25, 4 (Dec. 2021), 180–187. DOI:https://doi.org/10.35509/01239015.719.

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Published

2021-02-25 — Updated on 2021-12-23

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