Microbiological findings in patients with febrile neutropenia
Keywords:
Neutropenia/microbiology, neutropenia/diagnosis, neoplasms/complicationsAbstract
Introduction: Febrile neutropenia is a common complication of chemotherapy in patients with cancer and an important proportion of them are infected. Half the number of patients with febrile neutropenia have a microbiologically identified focus. We present the microbiological findings in patients with febrile neutropenia at the Instituto Nacional de Cancerología.
Materials and methods: Through an antibiotic surveillance program in the first quarter of 2003, patients with clinical diagnosis of febrile neutropenia were identified. Positive microbiological cultures of these patients were followed and analized with the help of the WHONET software.
Results: 128 patients with febrile neutropenia who received antibiotics were followed. 38% of them were from the pediatric service. 83 cultures with potentially infectious microorganisms were obtained from 45 patients. Gram-positive cocci were the most common finding, specially coagulase-negative Staphylococci. Among the Gram-negative bacilli, E. coli and K. pneumoniae were frequently found. Fungi represented 12% of the microorganisms. Antimicrobial resistance rates were high among isolated bacteria.
Discussion: At the Instituto Nacional de Cancerologia, Gram-positive cocci were the most common microbiological finding. Broad-spectrum antibiotic coverage should be used in this high-risk population. A close surveillance of antimicrobial resistance should be maintained.
Author Biographies
Jorge A. Cortés, Instituto Nacional de Cancerología
Grupo de Infectología, INC
Sonia I. Cuervo, Instituto Nacional de Cancerología
Grupo de Infectología, INC
Patricia Arroyo, Instituto Nacional de Cancerología
Grupo de Microbiología, Laboratorio Clínico, INC
Ruth Quevedo, Instituto Nacional de Cancerología
Grupo de Microbiología, Laboratorio Clínico, INC
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