Adrenocortical carcinoma: state of the art
Keywords:
Cushing síndrome, neoplasm metastasis, adrenal cortex neoplasmsAbstract
A 22 year-old woman presented with a 9-month history of a left breast tumor and a left adrenal mass in the context of a Cushing's syndrome. Her laboratory studies demonstrated high urinary cortisol excretion, abnormally elevated serum testosterone values, and suppressed ACTH. An abdominal CT scan revealed a mass in the left adrenal gland suggestive of adrenocortical cancer with distant metastasis to the liver and the lungs. Herein, we review and discuss the diagnosis and the therapeutic options for this rare and aggressive neoplasia.
Author Biographies
Nydia Elvira Pabón, Universidad Nacional de Colombia
Grupo Endocrinología; Universidad Nacional de Colombia, Bogotá, D.C., Colombia.
Constanza Gómez, Instituto Nacional de Cancerología
Grupo Patología Oncológica, Instituto Nacional de Cancerología E.S.E., Bogotá, D.C., Colombia.
Gloria Garavito, Instituto Nacional de Cancerología
Grupo Endocrinología Oncológica, Instituto Nacional de Cancerología E.S.E., Bogotá, D.C., Colombia
Camilo Jiménez, Instituto Nacional de Cancerología
Grupo Endocrinología Oncológica, Instituto Nacional de Cancerología E.S.E., Bogotá, D.C., Colombia
References
Geller JL, Mertens RB, Weiss L. Adrenocortical carcinoma many questions remain unanswered. The Endocrinologist 2005; 15:3009-312.
https://doi.org/10.1097/01.ten.0000179019.26435.ad
Schteingart DE, Doherty GM, Gauger PG. Management of patients with adrenal cancer: recommendations of an international consensus conference. Endocrine Related Cancer 2005; 12:667-80.
https://doi.org/10.1677/erc.1.01029
Pardo C, Murillo R, Piñeros M, Castro MA. Casos nuevos de cáncer en el Instituto Nacional de Cancerología, 2002. Rev Colomb Cancerol 2003; 7(3):4-19.
Allolio B, Hahner S, Weisman D et al. Management of adrenocortical carcinoma. Clin Endocrinol 2004;60:273-87.
https://doi.org/10.1046/j.1365-2265.2003.01881.x
Norton JA, LE Hop N. Adrenal Tumors. In: DeVita, VT. Cancer principles and paractice of oncology. 6 ed. Philadelphia, Lippincott Williams & Wilkins 2001 p.l 779-87.
Libe R, Bertherat J. Molecular genetics of adrenocortical tumours, from familial to sporadic diseases. Eur J Endocrinol 2005;153:477-87.
https://doi.org/10.1530/eje.1.02004
Sidhu S, Gicquel C, Bambach C et al. Clinical and molecular aspects of adrenocortical tumourigenesis. ANZ J Surg 2003;73:727-38.
https://doi.org/10.1046/j.1445-2197.2003.02746.x
J Bertherat, Gimenez-Roqueplo AP. New insights in the genetics of adrenocortical tumours, pheochromocytomas and paragangliomas. Horm Metab Res 2005;37:384-90.
https://doi.org/10.1055/s-2005-870156
Schteingart D. Current perspective in the diagnosis and treatment of adrenocortical carcinoma. Rev Endocrinol Metab Disorders 2001;2:323-33.
https://doi.org/10.1023/A:1011576702293
Stojainovic A, Ghossein R, Hoos A et al. Adrenocortical carcinoma: clinical, morphologic and molecular characterization. J Clin Oncol 2002;20:941-50.
https://doi.org/10.1200/JCO.2002.20.4.941
Francois C, Rangachari B, Bova D. Case report: mammography and sonography of pathologically provenadrenal cortical carcinoma metastasic to the breast. Am J Roentgenol 2005;184:1279-81.
https://doi.org/10.2214/ajr.184.4.01841279
Linda NG, Libertino JM. Adrenocortical carcinoma: diagnosis, evaluation and treatment. J Urol 2003;169:5-11.
https://doi.org/10.1016/S0022-5347(05)64023-2
Mansmann G, Lau J, Balk E et al. The clinically inapparent adrenal mass: update in diagnosis and management. Endocr Rev 2004;25:309-40.
https://doi.org/10.1210/er.2002-0031
Aiba M, Fujibayashi M. Histopathological diagnosis and prognostic factors in adrenocortical carcinoma. Endocr Pathol 2005;16:13-22.
https://doi.org/10.1385/EP:16:1:013
Saunders BD, Doherty GM. Laparoscopic adrenalectomy for malignant disease. Lancet 2004;5:718-26.
https://doi.org/10.1016/S1470-2045(04)01647-X
Chu PG, Weiss LM. Keratin expression in human tissues and neoplasms. Histopathology 2002;40: 403-39.
https://doi.org/10.1046/j.1365-2559.2002.01387.x
Chu PG, Wu E, Weiss L et al. Cytokeratin 7 and Cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol 2000:13:962-72.
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