Measuring Quality of Life among Cancer Patients in Clinical Trials. A Bibliometric Study
Keywords:
Quality of life, cancer, clinical trials, EORTC, outcome assessmentAbstract
Health Related Quality of Life (HRQL) refers to the evaluation a patient makes of his/her current functional state and sense of well-being compared to the ideal. The measurement of quality of life in clinical trials (CT) provides a more accurate evaluation on how well individual patients or groups of patients feel, and what benefits and adverse events might occur as a result of medical intervention. In oncological research, quality of life has been identified as the second most important outcome, preceded only by survival. In order to establish how quality of life evaluation was being carried out on clinical trials for cancer, we conducted a data base search at MEDLINE and LILACS. Following selection based upon elegibility criteria, 192 articles were chosen. The first CT to measure quality of life were published in 1992; the most frequently studied neoplasia was breast cancer; in the case of colorectal cancer, the trend was towards fewer quality of life measurement studies. Five studies were found in which non-specific instruments were utilized to measure the construct. Due to the relevance of quality of life, it is necessary to carry out similar searches to evaluate these measurements in other kinds of epidemilogical and pathological studies.
Author Biographies
Ricardo Sánchez, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología. Bogotá, Colombia.
Mónica Ballesteros, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología. Bogotá, Colombia.
Alejandro Gómez Aulí, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología. Bogotá, Colombia.
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