Digital Synovial Sarcoma

Authors

  • Alfredo Ernesto Romero Rojas Instituto Nacional de Cancerología
  • Ligia Inés Restrepo Escobar Instituto Nacional de Cancerología
  • Mario Alexánder Melo-Uribe Instituto Nacional de Cancerología
  • Julio Alexánder Díaz-Pérez Instituto Nacional de Cancerología

Keywords:

Synovial sarcoma, hand, immunohistochemestry

Abstract

Synovial sarcoma is a clinically and morphologically well defined entity which, in spite of its name, is rare in joint cavities. This sarcoma affects zones without any apparent relation to synovial structures and represents from 5% to 10% of all sarcomas in soft tissues. It is most frequently found in the extremities, especially the lower ones, where it tends to be located in the vicinity of the major articulations; there are very few favorable reports on the clinical evolution of synovial sarcomas in the hands or feet. It is most frequent between the ages of 15 to 40 (median age, 34). This article presents the case of an adult woman who underwent histopathologic and immunohistochemical diagnosis of a synovial sarcoma on the little finger of her right hand.

Author Biographies

Alfredo Ernesto Romero Rojas, Instituto Nacional de Cancerología

Instituto Nacional de Cancerología, Bogotá, Colombia.

Ligia Inés Restrepo Escobar, Instituto Nacional de Cancerología

Instituto Nacional de Cancerología, Bogotá, Colombia.

Mario Alexánder Melo-Uribe, Instituto Nacional de Cancerología

Instituto Nacional de Cancerología, Bogotá, Colombia.
Universidad Industrial de Santander (PATUIS), Bucaramanga, Colombia.

Julio Alexánder Díaz-Pérez, Instituto Nacional de Cancerología

Instituto Nacional de Cancerología, Bogotá, Colombia.
Universidad Industrial de Santander (PATUIS), Bucaramanga, Colombia.

References

Smith LW. Synoviomata. Am J Pathol. 1927;3(4):355-64.

https://doi.org/10.1093/nq/CLII.may14.355c

Lejars F, Rubens-Duval H. Les sarcomes primitifs des synoviales articulaires. Rev Chir (Paris). 1910;41:751-83.

Kransdorf MJ. Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol. 1995;164(1):129-34.

https://doi.org/10.2214/ajr.164.1.7998525

Herzog CE. Overview of sarcomas in the adolescent and young adult population. J Pediatr Hematol Oncol. 2005;27(4):215-8.

https://doi.org/10.1097/01.mph.0000161762.53175.e4

Ladanyi M, Antonescu CR, Leung Dh, Woodruff JM, Kawai A, Healey JH, et al. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multiinstitutional retrospective study of 243 patients. Cancer Res. 2002;62(1):135-40.

Raney RB. Synovial sarcoma in young people: background, prognostic factors, and therapeutic questions. J Pediatr Hematol Oncol. 2005; 27(4):207-11.

https://doi.org/10.1097/01.mph.0000161764.60798.60

Weiss S. Tumores malignos de origen incierto de partes blandas. En: Weiss S, Goldblum J. Tumores de partes blandas. Philadephia: Elsevier Mosby; 2009. p. 1161-82.

Namba Y, Kawai A, Naito N, Morimoto Y, Hanakawa S, Inoue H. Intraarticular sinovial sarcoma confirmed by SYT-SSX fusion transcript. Clin Orthop Relat Res. 2002;(395):221-6.

https://doi.org/10.1097/00003086-200202000-00026

Gallia GL, Sciubba DM, Hann CL, Raman SP, Westra WH, Tufaro AP, et al. Sinovial sarcoma of the frontal sinus. Case report. J Neurosurg. 2005;103(6):1077-80.

https://doi.org/10.3171/jns.2005.103.6.1077

Barkan GA, El-Naggar AK. Primary sinovial sarcoma of the parotid gland. Ann Diagn Pathol. 2004;8(4):233-6.

https://doi.org/10.1053/j.anndiagpath.2004.04.007

Hazelbag HM, Szuhai K, Tanke HJ, Rosenberg C, Hogendoorn PC. Primary sinovial sarcoma of the heart: a cytogenetic and molecular genetic analysis combining RT-PCR and COBRA-FISH of a case with a complex karyotype. Mod Pathol. 2004;17(11):1434-9.

https://doi.org/10.1038/modpathol.3800200

Begueret H, Galateau-Salle F, Guillou L, Chetaille B, Brambilla E, Vignaud JM, et al. Primary intrathoracic sinovial sarcoma: a clinicopathologic study of 40 t(X;18)-positive cases from the French Sarcoma Group and the Mesopath Group. Am J Surg Pathol. 2005;29(3):339-46.

https://doi.org/10.1097/01.pas.0000147401.95391.9a

Taylor SM, Ha D, Elluru R, El-Mofty S, Haughey B, Wallace M. Synovial sarcoma of the pericricoidal soft tissue. Otolaryngol Head Neck Surg. 2002;126(4):428-9.

https://doi.org/10.1067/mhn.2002.123833

Pan CC, Chang YH. Primary synovial sarcoma of the prostate. Histopathology. 2006;48(3):321-3.

https://doi.org/10.1111/j.1365-2559.2005.02236.x

Srivastana A, Nielsen PG, Dal Cin P, Rosenberg AE. Monophasic synovial sarcoma of the liver. Arch Pathol Lab Med. 2005;129(8):1047-9.

Suster S, Moran CA. Primary synovial sarcomas of the mediastinum: a clinicopathologic, immunohistochemical, and ultrastructural study of 15 cases. Am J Surg Pathol. 2005;29(5):569-78.

https://doi.org/10.1097/01.pas.0000157934.50936.3e

Ulusan S, Kizilkilic O, Yildirim T, Hurcan C, Bal N, Nursal TZ. Radiological findings of primary retroperitoneal synovial sarcoma. Br J Radiol. 2005; 78(926):166-9.

https://doi.org/10.1259/bjr/67990800

Billings SD, Meisner LF, Cummings OW, Tejada E. Synovial sarcoma of the upper digestive tract: a report of two cases with demonstration of the X;18 translocation by fluorescence in situ hybridization. Mod Pathol. 2000;13(1):68-76.

https://doi.org/10.1038/modpathol.3880011

Winnepenninckx V, De Vos R, Debiec-Rychter M, Samson I, Brys P, Hagemeijer A, et al. Calcifying/ossifying synovial sarcoma shows t(X;18) with SSX2 involvement and mitocondrial calcifications. Histopathology. 2001;38(2):141-5.

https://doi.org/10.1046/j.1365-2559.2001.01069.x

Krane JF, Bretoni F, Fletcher CD. Myxoid synovial sarcoma: an underappreciated morphologic subset. Mod Pathol. 1999;12(5):456-62.

Varela-Duran J, Enzinger FM. Calcifying synovial sarcoma. Cancer. 1982;50(2):345-52.

https://doi.org/10.1002/1097-0142(19820715)50:2<345::AID-CNCR2820500231>3.0.CO;2-Y

Milchgrub S, Ghandur-Mnaymneh L, Dorfman HD, Albores-Saavedra J. Synovial sarcoma with extensive osteoid and bone formation. Am J Surg Pathol. 1993;17(4):357-63.

https://doi.org/10.1097/00000478-199304000-00006

Folpe AL, Schmid RA, Chapman D, Gown AM. Poorly differentiated synovial sarcoma: immunohistochemical distinction from primitive neuroectodermal tumors and high-grade malignant peripheral nerve sheath tumors. Am J Surg Pathol. 1998;22(6):673-82.

https://doi.org/10.1097/00000478-199806000-00004

Van de Rijn M, Barr FG, Xiong QB, Hedges M, Shipley J, Fisher C. Poorly differentiated synovial sarcoma: an analysis of clinical, pathologic, and molecular genetic features. Am J Surg Pathol. 1999;23(1):106-12.

https://doi.org/10.1097/00000478-199901000-00012

De Silva MV, McMahon AD, Paterson L, Reid R. Identification of poorly differentiated synovial sarcoma: a comparison of clinicopathological and cytogenetic features with those of typical synovial sarcoma. Histopathology. 2003;43(3):220-30.

https://doi.org/10.1046/j.1365-2559.2003.01668.x

Meis-Kindblom JM, Stenman G, Kindblom LG. Differential diagnosis of small round cell tumors. Semin Diagn Pathol. 1996;13(3):213-41.

Guillou L, Wadden C, Kraus MD, Dei Tos AP, Fletcher CDM. S-100 protein reactivity in synovial sarcomas: a potentially frequent diagnostic pitfall; immunohistochemical analysis of 100 cases. Appl Immunohistochem. 1996;4:167-75.

Miettinen M, Limon J, Niezabitowski A, Lasota J. Patterns of keratin polypeptides in 110 biphasic, monophasic, and poorly differentiated synovial sarcomas. Virchows Arch. 2000; 437(3):275-83.

https://doi.org/10.1007/s004280000238

Olsen SH, Thomas DG, Lucas DR. Cluster analysis of immunohistochemical profiles in synovial sarcoma, malignant peripheral nerve sheath tumor, and Ewing sarcoma. Mod Pathol. 2006;19(5):659-68.

https://doi.org/10.1038/modpathol.3800569

Suster S, Fisher C, Moran CA. Expression of bcl-2 oncoprotein in benign and malignant spindle cell tumors of soft tissue, skin, serosal surfaces, and gastrointestinental tract. Am J Surg Pathol. 1998;22(7):863-72.

https://doi.org/10.1097/00000478-199807000-00008

Smith TA, Machen SK, Fisher C, Goldblum JR. Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from malignant peripheral nerve sheath tumor. Am J Clin Pathol. 1999;112(5):641-8.

https://doi.org/10.1093/ajcp/112.5.641

Sandberg AA, Bridge JA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma. Cancer Genet Cytogenet. 2002;133(1):1-23.

https://doi.org/10.1016/S0165-4608(01)00626-4

Ladanyi M. Fusions of the SYT and SSX genes in synovial sarcoma. Oncogene. 2001; 20(40):5755-62.

https://doi.org/10.1038/sj.onc.1204601

Nagayama S, Katagiri T, Tsunoda T, Hosaka T, Nakashima Y, Araki N, et al. Genome-wide analysis of gene expression in synovial sarcomas using a cDNA microarray. Cancer Res. 2002;62(20):5859-66.

Spillane AJ, A'Hern R, Judson IR, Fisher C, Thomas JM. Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment. J Clin Oncol. 2000;18(22):3794-803.

https://doi.org/10.1200/JCO.2000.18.22.3794

Trassard M, Le Doussal V, Hacene K, Terrier P, Ranchère D, Guillou L, et al. Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adult patients. J Clin Oncol. 2001;19(2):525-34.

https://doi.org/10.1200/JCO.2001.19.2.525

How to Cite

[1]
Romero Rojas, A.E. et al. 2009. Digital Synovial Sarcoma. Revista Colombiana de Cancerología. 13, 3 (Sep. 2009), 175–180.

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