Survival in Patients with Brain Metastases Treated with Whole Brain Radiotherapy at the Instituto Nacional de Cancerología
Keywords:
Survival analysis, neoplasm metastasis, central nervous system, radiotherapy, follow-up studies, ColombiaAbstract
Objective: To describe the overall survival among patients with brain metastases treated with whole brain radiation therapy at the Instituto Nacional de Cancerología (INC) during 2004-2006.
Methods: A survival study was conducted. All patients with brain metastases treated with whole brain radiotherapy were included. Frequencies, central tendency, and dispersion measures were used to describe discrete and continuous variables. Survival analysis was performed by the Kaplan-Meyer method.
Results: 109 patients were included and the vital status was updated in 85 patients (80%). The median follow-up time was 2.76 months. 78 deaths were observed; the median survival time was 5.2 months and the cumulated one-year overall survival 25.5%. Karnofsky index, extra-cranial metastases, type of lesion, and recursive partitioning analysis (RPA) were significant prognostic factors. The overall median survival for recursive partitioning analysis class I was 7.2 months; class II 6.9 months; class III 1.8 months.
Conclusion: Overall survival INC are similar than previous international series for RPA class I and III, while it was better in RPA class II.
Author Biographies
Rosalba Ospino, Instituto Nacional de Cancerología
Grupo de Radioterapia, Instituto Nacional de Cancerología, Bogotá, Colombia.
Ricardo Cendales, Instituto Nacional de Cancerología
Grupo de Radioterapia, Instituto Nacional de Cancerología, Bogotá, Colombia.
Jaime Triana, Instituto Nacional de Cancerología
Grupo de Radioterapia, Instituto Nacional de Cancerología, Bogotá, Colombia.
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