Large Cell Calcifying Sertoli Cell Tumor Associated with Peutz-Jeghers Syndrome
Keywords:
Neoplasm, Sertoli cell tumor, Peutz-Jeghers syndrome, immunohistochemistryAbstract
The large cell calcifying Sertoli cell tumor (LCCSCT) is a very rare testicular tumor with 60 cases reported worldwide; in Latin America and Colombia, few cases are reported in the literature. This neoplasm originates in the gonadal stromal/sex cord, and, in general, tends to display benign biological behavior. It is thought that these tumors may display differing characteristics: depending upon whether they occur in the context of a complex congenital syndrome, in which case they tend to be bilateral and multifocal; as opposed to those not associated with syndromes, which tend to be unilateral and focal. Immunohistochemical study is essential for diagnosis, in particular, to differentiate these tumors from germ cell tumors. This study reports on three cases of this tumor--one associated with Peutz-Jeghers Syndrome—and emphasis is given to histological criteria to define malignancy.
Author Biographies
José Tovar, Instituto Nacional de Cancerología
Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
Fundación Universitaria de Ciencias de la Salud, Bogotá D.C., Colombia
Oscar Messa, Instituto Nacional de Cancerología
Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
Sandra Chinchilla, Instituto Nacional de Cancerología
Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
Alfredo Romero, Instituto Nacional de Cancerología
Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
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