Inmunomagnetic Detection of Circulating Tumor Cells in Metastatic Breast Cancer: New Technologies
Keywords:
Circulating tumour cells, breast cancer, immunomagnetic and metastasisAbstract
Hematogenous metastasis is the major cause of mortality in breast cancer. Evidence indicates that tumor cells escape from the primary tumor mass into the blood stream and that these disseminated cells are the source of increased lethality. Circulating or metastatic tumour cells have been considered as useful indicators of the aggressiveness of breast cancer tumours. The first clinical results obtained with such assays strongly suggest that in metastatic breast cancer, circulating tumour cells detection and enumeration can be used to estimate prognosis and may serve as an early marker to assess anti-tumour activity of a treatment. Immunomagnetic analysis using a new methodology, determine that a circulating tumour cells count of 5 or more per 7,5 ml of blood, at any time during the course of the disease is associated with a poor prognosis and is predictive of shorter progression and overall survival.
Author Biographies
Luz F. Sua, Universidad del Valle
Departamento de Anatomía y Patología Clínica, Universidad del Valle, Cali, Colombia
Unidad Oncológica, Clínica de Occidente S. A., Colombia
Nhora M. Silva, Fundación Clínica Valle del Lili
Laboratorio Clínico y de Patología, Fundación Clínica Valle del Lili, Cali, Colombia
Marta Vidaurreta, Hospital Clínico San Carlos
Servicio de Ginecología, Hospital Clínico San Carlos, Madrid, España
María L. Maestro, Hospital Clínico San Carlos
Servicio de Ginecología, Hospital Clínico San Carlos, Madrid, España
Sara R. Fernández, Hospital Clínico San Carlos
Servicio de Ginecología, Hospital Clínico San Carlos, Madrid, España
Silvia Veganzones, Hospital Clínico San Carlos
Servicio de Ginecología, Hospital Clínico San Carlos, Madrid, España
Virginia de la Orden, Hospital Clínico San Carlos
Servicio de Ginecología, Hospital Clínico San Carlos, Madrid, España
José M. Román, Hospital Clínico San Carlos
Laboratorio de Análisis Clínicos, Hospital Clínico San Carlos, Madrid, España
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