Tumor of granular cells in the axillar region: purpose of a case and literature review
DOI:
https://doi.org/10.35509/01239015.477Keywords:
Granular cell tumor, breast, axillary, SchwannAbstract
Germ cell tumors (GCT) are the most common malignant neoplasms affecting young men aged 15 to 35. Relapsing patients with stage 2 and 3 pose a major challenge to the medical team. The optimal therapy for these patients with recurrent disease depends on their initial treatment, and is still poorly defined. Options include second-line chemotherapy regimens at conventional doses that combine cisplatin and ifosfamide, with vinblastine, etoposide or paclitaxel, or alternatively high-dose chemotherapy with stem cell support. Given that there is still no conclusive evidence from clinical trials, indications for using high-dose chemotherapy remain unclear and are based on predominantly retrospective studies. Second-relapse treatment options should be individualized according to the patient and the previous treatment. Surgical resection of residual masses in patients after chemotherapy is a key element for successful therapy in patients with negative tumor markers. Currently, relapsing patients in Venezuela have to be treated with any of the established regimens used at conventional second-line doses. However, in some cases they must receive treatment in an oncology center with a multidisciplinary team, having access to treatment with high-dose chemotherapy and to oncologist surgeons experts in this area.
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