Meningeal carcinomatosis as first manifestation of gastric carcinoma
Keywords:
Meningeal carcinomatosis, stomach neoplasms, autopsy, immunohistochemistry.Abstract
Meningeal carcinomatosis is defined as the malignant and widespread infiltration of the meninges due to the planting and growth of cancer cells within the leptomeningeal space. It occurs more frequently in patients with disseminated neoplastic disease, but it may occur after a disease free interval and may even be the first manifestation of cancer. The most common primary tumors in adults are breast (30-50%), lung (15-25%), melanoma (11%) and gastric cancer (0.16-0.69%); in marked contrast with pediatric cases in which lymphocytic leukemia is the most common. The following article describes an autopsy case of a patient with psychiatric symptoms, with no antecedents of importance, with progressive and fatal neurological impairment, whose pathological studies show meingeal carcinomatosis attributable to advanced gastric adenocarcinoma discovered de novo post mortem.
Author Biographies
Alfredo Ernesto Romero Rojas, Instituto Nacional de Cancerología
Grupo de Patología, Instituto Nacional de Cancerología, Bogotá. Colombia.
Julio César Mantilla Hernández, Universidad Industrial de Santander
Grupo de patología, Universidad Industrial de Santander, Bucaramanga. Colombia.
Mario Alexánder Melo Uribe, Universidad Industrial de Santander
Grupo de patología, Universidad Industrial de Santander, Bucaramanga. Colombia.
Paula Alejandra Barajas Solano, Universidad Industrial de Santander
Grupo de patología, Universidad Industrial de Santander, Bucaramanga. Colombia.
Sandra Isabel Chinchilla Olaya, Instituto Nacional de Cancerología
Grupo de Patología, Instituto Nacional de Cancerología, Bogotá. Colombia.
References
Baiges-Octavio JJ, Huerta-Villanueva M. Carcinomatosis meníngea. Rev Neurol. 2000;31:1237-8.
https://doi.org/10.33588/rn.3112.2000091
Eberth CJ. Zur Entwicklung des Epitheliomas (Cholesteatomas) dur Pia under der Lungs. Virchow's Arch. 1870;49:51-63.
https://doi.org/10.1007/BF02214196
Baba S, Matsuda H, Gotoh M, Shimada K, Yokoyama Y, Sakanushi A. A case of meningeal carcinomatosis presenting with the primary symptoms of facial palsy and sensorineural deafness. J Nippon Med Sch. 2006;73(4):240-3.
https://doi.org/10.1272/jnms.73.240
Lee JL L, Kang YK, Kim TW, Chang HM, Lee GW, Ryu MH, et al. Leptomeningeal carcinomatosis in gastric cancer. J Neurooncol. 2004;66(1-2):167-74.
https://doi.org/10.1023/B:NEON.0000013462.43156.f4
Lisenko Y, Kumar AJ, Yao J, Ajani J, Ho L. Leptomeningeal carcinomatosis originating from gastric cancer. Report of eight cases and review of the literature. Am J Clin Oncol. 2003;26(2):165-70.
https://doi.org/10.1097/00000421-200304000-00013
Chamberlain MC. Neoplastic meningitis. Oncologist. 2008;13(9):967-77.
https://doi.org/10.1634/theoncologist.2008-0138
Camacho DE, Rengifo Y, Hurtado H, Collazos T. Incidencia de carcinoma gástrico en Cali. Colombia Médica. 1995;26:146-9.
Bermúdez C, Insuasty J, Gamarra G. Grupo sanguíneo A y riesgo de cáncer gástrico en el Hospital Universitario de Santander (Bucaramanga, Colombia). Acta Med Colomb. 2006;31(4):400-10.
Colombia, Ministerio de la Protección Social, Instituto Colombiano de Cancerología. Anuario estadístico 2006. Bogotá: Ministerio de la Protección social, Instituto Nacional de Cancerología; 2007.
Kokkoris CP. Leptomeningeal carcinomatosis. How does cancer reach the pia-arachnoid? Cancer. 1983;51(1):154-60.
https://doi.org/10.1002/1097-0142(19830101)51:1<154::AID-CNCR2820510130>3.0.CO;2-K
Demopoulos A. Leptomeningeal metastases. Current neurology and neuroscience reports. 2004;4(3):196-204.
https://doi.org/10.1007/s11910-004-0039-z
Wasserstrom WR, Glass J, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer. 1982;49(4):759-72.
https://doi.org/10.1002/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO;2-7
Pavlidis N. The diagnostic and therapeutic management of leptomeningeal carcinomatosis. Ann Oncol. 2004;15(4):285-91.
https://doi.org/10.1093/annonc/mdh941
Tonomura Y, Kataoka H, Terashima M, Shinkai T, Ueno S. Detection of neoplastic meningitis in a patient with gastric cancer by thallium-201 SPECT. Radiology Case. 2009; 3(4):9-13.
https://doi.org/10.3941/jrcr.v3i4.157
Giglio P, Weinberg JS, Forman AD, Wolff R, Groves MD. Neoplastic meningitis in patients with adenocarcinoma of the gastrointestinal tract. Cancer. 2005;103(11):2355-62.
https://doi.org/10.1002/cncr.21082
Raj KP, Sanati H, Mehta RS, Zell JA. Need for a new treatment strategy: leptomeningeal carcinomatosis from gastric cancer. Anti-Cancer Drugs. 2009;20(4):301-4.
https://doi.org/10.1097/CAD.0b013e328329707c
Waki F, Ando M, Takashima A, Yonemori K, Nokihara H, Miyake M, et al. Prognostic factors and clinical outcomes in patients with leptomeningeal metastasis from solid tumors. J Neurooncol. 2009;93(2):205-12.
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Todos los derechos reservados.
