Technical note: Recommendations for Processing Bone Specimens in Pathology: Practice at the National Cancer Institute of Colombia
Keywords:
Pathology, processing, bone, neoplasms, calcium, review of literatureAbstract
The processing and study of bone biopsias represent a challenge for the pathologist due to the complexity of diagnosis. Bone samples require special processing such as the manipulation and decalcification of big surgical specimens in order to obtain evaluable tissue under the microscope. Consequently, the pathology is performed in about 20-30 days delaying the final diagnosis, the beginning of treatment, or the evaluation of neoadyuvant therapy response. A practical guideline for bone specimen processing was developed reducing layout time for final diagnosis around 2-3 days for biopsies and 13-15 days for surgical specimens. A practical, nimble, and reliable guideline is presented.
Author Biographies
Diana Lizcano, Fundación Universitaria de Ciencias de la Salud
Grupo de Patología, Fundación Universitaria de Ciencias de la Salud (FUCS), Hospital San José, Bogotá, D.C., Colombia
Ligia Restrepo, Instituto Nacional de Cancerología
Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Alfredo Romero, Instituto Nacional de Cancerología
Grupo de Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
References
Dimenstein IB. Bone grossing techniques: helpful hints and procedures. Ann Diagn Pathol. 2008;12:191-8.
https://doi.org/10.1016/j.anndiagpath.2007.06.004
Dorfman HD, Czerniak B (editors). Bone tumors. St. Louis: Mosby; 1998.
García del Moral, R. (editor). Laboratorio de anatomía patológica. Madrid: McGraw-Hill Interamericana de España; 1993.
Prophet E, Mills B (editores). Métodos histotecnológicos. Instituto de Patología de las Fuerzas Armadas de los Estados Unidos de América. Maryland: AFIP; 1995.
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