Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma: a Histological Type With Difficult Diagnosis
Keywords:
Thyroid neoplasms, carcinoma, papillary, diagnosisAbstract
The papillary thyroid carcinoma is the most frequent thyroid neoplasm and usually it is a non aggressive tumor; nevertheless, some histological variants such as the diffuse sclerosing variant are more aggressive producing locoregional invasion and distant metastasis. This specific variant challenges the pathological diagnosis since the architectural and cytological characteristics might be confusing, particularly regarding benign lesions such as the lymphocytic thyroiditis. We present a case report of a patient at the National Cancer Institute of Colombia with a lung metastasis from a diffuse sclerosing papillary thyroid carcinoma. The difficulties for diagnosis, for both clinical and pathology experts, are illustrated as well as their relevance for determining the biological course of the disease.
Author Biographies
Alfredo Romero, Instituto Nacional de Cancerología
Grupo de Patología, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia
Ivonne Meza, Universidad del Cauca
Grupo de Patología, Universidad del Cauca, Popayán, Colombia
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