Gastrointestinal Stromal Tumors (GIST) at the National Cancer Institute, Bogota D.C., Colombia 2000-2008
Keywords:
Gastrointestinal Stromal Tumors, Prognosis, Treatment Outcome, Tumor Markers, Biological, Proto-Oncogene Proteins c-kit, Ki-67 AntigenAbstract
Objective: To describe the demographic, clinical and pathological characteristics, as well as diagnosis, treatment and follow up in patients with gastrointestinal stromal tumors (GIST) at the National Cancer Institute (NCI) between 2000 and 2008.
Methods: A retrospective study was carried out on 39 patients diagnosed with GIST in which the diagnostic pathology and immunohistochemical clinical characteristics were analyzed, as were prognostic factors such as size, mitotic count and localization. Surgical and medical procedures along with follow up and recurrence were reviewed in relation to lesion localization.
Results: The study included 39 patients with an average age of 53 years. Most common localization was the stomach (16 cases), followed by the small intestine (9 cases). Out of total number of patients, 24 had lesions greater than 10 cm. and 19 had lesions less than 5 mitosis x 50 fields. All but one lesion tested CD117 positive. Abdominal pain was the most common symptom. Of the 39 patients, 7 had metastasis at time of diagnosis. Preoperative biopsy was taken on 43.7% of patients, and 38 patients underwent surgery; 8 of whom for intestinal obstruction in the small intestine. Follow up ranged from 2 to 72 months. Relapse occurred in 16 cases, for a rate of 1.26 per 100 patients. Median survival rate was 48.53 months.
Conclusions: GISTs make up a group of tumors with ever increasing diagnosis due to clinical suspicion and immunohistochemical diagnosis. Treatment is primarily surgical, but adjuvant and neo-adjuvant ITK treatment are currently used to treat this pathology.
Author Biographies
Ricardo Oliveros, Instituto Nacional de Cancerología
Grupo de Cirugía Gastrointestinal y Endoscopia Digestiva, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
Álvaro Pío Quintero, Hospital San Rafael
Grupo de Gastroenterología y Endoscopia Digestiva, Hospital San Rafael, Tunja, Colombia
Ricardo Sánchez, Instituto Nacional de Cancerología
Grupo de Investigación Clínica, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
Universidad Nacional de Colombia, Bogotá D.C., Colombia
Jorge Andrés Mesa, Instituto Nacional de Cancerología
Grupo de Patología, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
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