Malnutrition as a Prognostic Factor for Survival of Pediatric Cancer Patients at a Colombian Institution
Keywords:
Desnutrition, Survival, Neoplasms, Pediatric AssistansAbstract
Objective: To determine if malnutrition is a prognostic factor in the survival of children with cancer.
Methods: A retrospective evaluation was carried out on a cohort of 471 pediatric patients recently diagnosed with cancer; patients´ overall survival and relapse free rates up to 60 months follow up was determined by Kaplan-Meier in accordance with nutritional state at diagnosis, measured by anthropometric index Z- score for weight and height according to age. The multivariable Cox regression analysis was used to evaluate the effect of nutritional state on survival in relation to demographic and oncological variables.
Results: Overall survival at 12 months was lower among the malnourished classified by weight and height Z- score according to age. The Z- weight score according to age influenced survival independent of other variables, p=0.027, adjusted risk cause at 3.3, 95% confidence interval: 1.1-9.5.
Conclusions: Malnutrition as classified by Z-weight and height score according to age at admission is an adverse prognostic factor for the overall survival of pediatric cancer patients. The effect of malnutrition on pediatric cancer patients remains controversial.
Author Biographies
Gloria Suárez, Instituto de Cancerología Clínica Las Américas
Instituto de Cancerología Clínica Las Américas, Medellín, Colombia
Gabriel Cano, Instituto de Cancerología Clínica Las Américas
Instituto de Cancerología Clínica Las Américas, Medellín, Colombia
Libia Rodríguez, Universidad Pontificia Bolivariana
Facultad de Medicina, Universidad Pontificia Bolivariana, Medellin, Colombia
Grupo de inmunología Celular e Inmunogenética, Universidad de Antioquia, Medellin, Colombia
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