Treatment of Basal-Cell Carcinoma with Systemic Photodynamic Therapy
Keywords:
Neoplasms, phototherapy, carcinoma, basal cellAbstract
Objective: To evaluate therapeutic response, among Venezuelan patients, to photodynamic therapy for basal-cell carcinoma with a chlorine-based photo-sensitizer compound.
Methods: Patients included in the study had been diagnosed with single or multiple basal- cell carcinomas, based on histopathology for adults, without gender or lesion localization discrimination, and were injected intravenously with the photo-sensitizer, Photolon. After a 3-hour interval, the tumoral zone (or zones) was illuminated with a 662 nm wave length diode laser.
Results: Treatment was performed on 43 lesions in 16 patients with favorable response in every case; all clinical evidence of tumor(s) disappeared, which was confirmed by histopathology. Patients presented no complications attributable to treatment and remained under observation with no signs of oncologic disease for 24 months.
Conclusions: The efficiency and utility of photodynamic therapy with Photolon was demonstrated in the treatment of Venezuelan patients with multiple basal cell carcinoma lesions.
Author Biographies
Jorge Castro, Servicio Oncológico Hospitalario del Instituto Venezolano de los Seguros Sociales
Unidad de Cirugía Plástica, Servicio Oncológico Hospitalario del Instituto Venezolano de los Seguros Sociales (IVSS), Caracas, Venezuela
Humberto Cabrera, Instituto Venezolano de Investigaciones Científicas
Laboratorio de Óptica Aplicada, Instituto Venezolano de Investigaciones Científicas (IVIC). Mérida, Venezuela
The Abdus Salam International Centre for Theoretical Physics (ICTP), Trieste, Italia
Cristina Grassi, Universidad de Los Andes
Facultad de Farmacia y Bioanálisis, Universidad de Los Andes (ULA), Mérida, Venezuela
Efrén D. Andrades, Universidad de Los Andes
Facultad de Farmacia y Bioanálisis, Universidad de Los Andes (ULA), Mérida, Venezuela
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