Characteristics of primary cutaneous melanoma in the Colombian National Cancerology Institute 2006-2010

Authors

  • Flavia Pozzobona Universidad Nacional de Colombia
  • Álvaro Acosta Instituto Nacional de Cancerología
  • Alexander Carreño Instituto Nacional de Cancerología
  • Eduardo Fierro Universidad Nacional de Colombia

Keywords:

Cutaneous melanoma, Skin cancer, Epidemiology, Colombia
Abstract Authors References How to Cite

Abstract

Objectives: To describe the main characteristics of cutaneous melanoma in the National Cancerology Institute, a cancer reference center in Bogota, Colombia.
Materials and methods: A descriptive, retrospective study was conducted on the demographic, clinical and histological characteristics of patients diagnosed with primary cutaneous melanoma in the National Cancerology Institute between 2006 and 2010
Results: A total of 599 patients were included, of whom 57.4% were females (n= 344) and 42.6% males (n=255). The mean age at diagnosis was 60.8 years. The majority of cases, 56.3% (n=329), were from Bogota. It was also the most common urban area where the patients had their usual residence (n=500). The mean annual frequency was 115 new cases per year. The most frequent location was acral, with 42.2% (n=253), followed by head and neck (n=186). In accordance with the location, the most common sub-type was acral lentiginous melanoma, with con 43.7% (n=262), followed by lentigo maligna, with 24% (n=144). As regards the depth, a similar frequency was observed for melanomas in situ and melanomas with Breslow >4 mm, both with 19% of the cases. It was found that the large majority of the lentigo maligna, 75% (n=108) were in situ or with a Breslow ≤1 mm. On the other hand, acral lentiginous and nodular melanomas had a higher frequency of Breslow >4 mm (with 26.3% n=69 and 45.4% n=10, respectively). Stage III was the most common stage, with 26.2% (n=157) of the cases.
Conclusions: A higher percentage of melanomas were observed in women, as well as a higher frequency of acral melanomas. A significant number of patients were in an advanced stage, thus greater action is required for the early detection of melanoma.

Author Biographies

Flavia Pozzobona, Universidad Nacional de Colombia

Universidad Nacional de Colombia, Bogotá, D. C., Colombia

Álvaro Acosta, Instituto Nacional de Cancerología

Clínica de Piel, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia

Alexander Carreño, Instituto Nacional de Cancerología

Grupo de Investigación Clínica, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia

Eduardo Fierro, Universidad Nacional de Colombia

Universidad Nacional de Colombia, Bogotá, D. C., Colombia

References

Tucker MA. Melanoma epidemiology. Hematol Oncol Clin North Am. 2009;23:383-95, vii.

Bradford PT, Goldstein AM, McMaster ML, Tucker MA. Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. Arch Dermatol. 2009;145:427-34.

https://doi.org/10.1001/archdermatol.2008.609

Rigel DS. Epidemiology of melanoma. Semin Cutan Med Surg. 2010;29:204-9.

https://doi.org/10.1016/j.sder.2010.10.005

Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998;83:1664-78.

https://doi.org/10.1002/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G

Eisemann N, Jansen L, Holleczek B, Waldmann A, Luttmann S, Emrich K, et al. Up-to-date results on survival of patients with melanoma in Germany. Br J Dermatol. 2012;167:606-12.

https://doi.org/10.1111/j.1365-2133.2012.11039.x

Desmond RA, Soong S. Epidemiology of malignant melanoma. Surg Clin North Am. 2003;83:1-29.

https://doi.org/10.1016/S0039-6109(02)00092-0

Marks R. Epidemiology of melanoma. Clin Exp Dermatol. 2000; 25:459-63.

https://doi.org/10.1046/j.1365-2230.2000.00693.x

Garbe C, Leiter U. Melanoma epidemiology and trends. Clin Dermatol. 2009;27:3-9.

https://doi.org/10.1016/j.clindermatol.2008.09.001

Acosta ÁE, Fierro E, Velásquez VE, Rueda X. Melanoma: patogénesis, clínica e histopatología. Revista Asociación Colombiana Dermatología. 2009;17:87-108.

Ferlay J, Shin HR, Bray F, Forman D, Mathers C PD. GLOBOCAN 2008 v2.0. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. Lyon, Francia: International Agency for Research on Cancer; 2010 [consultado 1 Sep 2012]. Disponible en: http://globocan.iarc.fr

Marrett LD, Nguyen HL, Armstrong BK. Trends in the incidence of cutaneous malignant melanoma in New South Wales, 1983-1996. Int J Cancer. 2001;92:457-62.

https://doi.org/10.1002/ijc.1203

Purdue MP, Freeman LEB, Anderson WF, Tucker MA. Recent trends in incidence of cutaneous melanoma among US Caucasian young adults. J Invest Dermatol. 2008;128:2905-8.

https://doi.org/10.1038/jid.2008.159

Aitken JF, Barbour A, Burmeister B, Taylor S, Walpole E, Network AC, et al. Clinical practice guidelines for the management of melanoma in Australia and New Zealand. New Zealand: Cancer Council Australia; Australian Cancer Network; Ministry of Health; 2008. p. 1-246.

Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Reintgen DS, Cascinelli N, et al. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol. 2001;19:3622-34.

https://doi.org/10.1200/JCO.2001.19.16.3622

Buettner PG, Leiter U, Eigentler TK, Garbe C. Development of prognostic factors and survival in cutaneous melanoma over 25 years: An analysis of the Central Malignant Melanoma Registry of the German Dermatological Society. Cancer. 2005;103:616-24.

https://doi.org/10.1002/cncr.20816

Buendía Eisman A, Ortega del Olmo RM, Serrano Ortega S. ¿Han cambiado nuestros melanomas? Actas Dermosifiliogr. 88:13-8.

Baade PD, English DR, Youl PH, McPherson M, Elwood JM, Aitken JF. The relationship between melanoma thickness and time to diagnosis in a large population-based study. Arch Dermatol. 2006;142:1422-7.

https://doi.org/10.1001/archderm.142.11.1422

Bono A, Tolomio E, Bartoli C, Carbone A, Tomatis S, Zurrida S, et al. Metamorphosis of melanoma. Trends in size and thickness of cutaneous melanoma over one decade at the Istituto Nazionale Tumori, Milan. Tumori. 94:11-3.

https://doi.org/10.1177/030089160809400103

Schmerling R a, Loria D, Cinat G, Ramos WE, Cardona AF, Sánchez JL, et al. Cutaneous melanoma in Latin America: the need for more data. Revista panamericana de salud pública=Pan American Journal of Public Health. 2011;30:431-8.

https://doi.org/10.1590/S1020-49892011001100005

Loria DI, González A, Latorre C. Epidemiología del melanoma cutáneo en Argentina : análisis del Registro Argentino de Melanoma Cutáneo. Cutaneous melanoma epidemiology in Argentina: analysis from the Argentine Cutaneous Melanoma Registry.

Nova-Villanueva J, Sánchez-Vanegas G, Porras de Quintana L. Cáncer de piel: perfil epidemiológico de un centro de referencia en Colombia 2003-2005. Revista de Salud Pública. 2007;9:595-601.

https://doi.org/10.1590/S0124-00642007000400012

Registro Poblacional de Cáncer de Cali [Internet] [consultado 17 Dic 2011]. Disponible en: http://rpcc.univalle.edu.co/es/index.php

Villegas M, Jaramillo F. Comportamiento clínico, epidemiológico e histológico del melanoma maligno en el Departamento de Caldas (Colombia). Rev Asoc Colomb Dermatol. 1999;7:192-6.

Curado M, Edwards B, Shin H, Storm H, Ferlay J, Heanue M, et al. Cancer incidence in five continents, Vol. IX. IARC Scientific Publications No. 160. [IARC]; 2007.

Colmenares L, Velazquez M, Vargas G. Melanoma lentiginoso acral : una variante de melanoma maligno de especial interés en Colombia. Iatrea. 2008;21:386-97.

Anuario estadístico 2010 [Internet]. Instituto Nacional de Cancerología. Ministerio de la protección socia [consultado 1 Sep 2012]. p. 63-4. Disponible en: http://www.cancer.gov.co/contenido/contenido.aspx?catID=437&conID=747

Sober AJ. Cutaneous melanoma: practical usefulness of the American Joint Committee on Cancer staging system. Dermatol Ther. 2005;18:407-11.

https://doi.org/10.1111/j.1529-8019.2005.00047.x

Ferrari NM, Muller H, Ribeiro M, Maia M, Sanches JA. Cutaneous melanoma: descriptive epidemiological study. Sao Paulo Med J. 2008;126:41-7.

https://doi.org/10.1590/S1516-31802008000100008

Gutierrez C, Alarcón E, Valle R, Calderón G. Epidemiología del melanoma maligno en el Instituto Nacional de Enfermedades Neoplásicas, Perú, 2000-2004. Folia dermatol Perú. 2007;18:23-7.

Anger M, Friedhofer H, Fukutaki MF, Ferreira MC, Landman G. Primary cutaneous melanoma: an 18-year study. Clinics (São Paulo, Brazil). 2010;65:257-63.

https://doi.org/10.1590/S1807-59322010000300004

Zalaudek I, Catricalà C, Moscarella E, Argenziano G. What dermoscopy tells us about nevogenesis. J Dermatol. 2011;38:16-24.

https://doi.org/10.1111/j.1346-8138.2010.01141.x

Soudry E, Gutman H, Feinmesser M, Gutman R, Schachter J. "Gloves-and-socks" melanoma: does histology make a difference? Dermatol Surg. 2008;34:1372-8.

https://doi.org/10.1111/j.1524-4725.2008.34290.x

Phan A, Touzet S, Dalle S, Ronger-Savlé S, Balme B, Thomas L. Acral lentiginous melanoma: histopathological prognostic features of 121 cases. Br J Dermatol. 2007;157:311-8.

https://doi.org/10.1111/j.1365-2133.2007.08031.x

Zegarra R. Situación del melanoma maligno cutáneo en el hospital militar central de Lima, 1985-2007. Dermatol Perú. 2008;18:267-83.

Lopez H, Gutierrez R, Posso H. Melanoma cutáneo maligno. Revista del Instituto Nacional de Cancerología. 1993;2:8-17. 36. Departamento Administrativo Nacional de Estadística (DANE) [Internet]. Bogotá, Colombia [consultado 24 Sep 2012]. p. 7. Disponible en: http://www.dane.gov.co/files/censo2005/etnia/sys/visibilidad_estadistica_etnicos.pdf

Whiteman DC, Stickley M, Watt P, Hughes MC, Davis MB, Green AC. Anatomic site, sun exposure, and risk of cutaneous melanoma. J Clin Oncol. 2006;24:3172-7.

https://doi.org/10.1200/JCO.2006.06.1325

Iribarren BO, Sepúlveda TM, Hidalgo GJ, Madariaga GJ. Estudio epidemiológico de melanoma maligno en la IV Región de Chile. Cuadernos de Cirugía. 2005;19:33-8.

https://doi.org/10.4206/cuad.cir.2005.v19n1-06

Roh MR, Kim J, Chung KY. Treatment and outcomes of melanoma in acral location in Korean patients. Yonsei Med J. 2010;51:562-8. 40. Grange F. [Epidemiology of cutaneous melanoma: descriptive data in France and Europe]. Ann Dermatol Venereol. 2005; 132(12 Pt 1):975-82.

https://doi.org/10.3349/ymj.2010.51.4.562

Lindholm C, Andersson R, Dufmats M, Hansson J, Ingvar C, Möller T, et al. Invasive cutaneous malignant melanoma in Sweden, 1990-1999. A prospective, population-based study of survival and prognostic factors. Cancer. 2004;101:2067-78.

https://doi.org/10.1002/cncr.20602

MacKie RM, Hauschild a, Eggermont a MM. Epidemiology of invasive cutaneous melanoma. Ann Oncol. 2009;20 Suppl 6:vi1-7. 43. MacKie RM, Bray C, Vestey J, Doherty V, Evans A, Thomson D, et al. Melanoma incidence and mortality in Scotland 1979-2003. Br J Cancer. 2007;96:1772-7.

https://doi.org/10.1038/sj.bjc.6603801

Mesa J, Jaramillo F, Benjumea M. Factores relacionados con la consulta tardía a dermatología por cáncer de piel. Prueba piloto. Departamento de Caldas. Promocion Salud. 2008;13:178-94.

Betti R, Vergani R, Tolomio E, Santambrogio R, Crosti C. Factors of delay in the diagnosis of melanoma. Eur J Dermatol. 2003;13:183-8.

How to Cite

[1]
Pozzobona, F. et al. 2013. Characteristics of primary cutaneous melanoma in the Colombian National Cancerology Institute 2006-2010. Revista Colombiana de Cancerología. 17, 3 (Sep. 2013), 111–118.

Downloads

Download data is not yet available.

Downloads

Published

2013-09-01

Issue

Vol. 17 No. 3 (2013)

Section

Research/original articles

License

Todos los derechos reservados.