Metastatic paraganglioma: image with F18-FDG- PET/CT
Keywords:
Positron emission tomography, Paragangliomas, StagingAbstract
The paragangliomas are a rare neuroendocrine group of tumors that can occur anywhere along paraganglia system. Most of them are benign and of slow progression, however about 10% of them will have metastases. The large majority (80-85%) of these tumorsarise from the adrenal medulla and are called pheochromocytomas, while 15-20% originate in chromaffin tissue at extra-adrenal sites, and are called paragangliomas. There are inherited variants (25%), and the disease may also present with multifocality. They can appear anywhere in paraganglia system and may be associated with sympathetic nervous tissue (adrenal medulla, the organ of Zuckerkandl, or other chromaffin cells that can persist beyond embryogenesis), or the parasympathetic nervous system (chemoreceptors, which are found mainly in the head and neck). Therefore, paragangliomas can be distributed from the base of the skull to the sacrum. Nuclear medicine imaging can help to fully define the disease.
Author Biography
Alejandro Martí Samper, Instituto Nacional de Cancerología
Grupo de Medicina Nuclear-PET, Instituto Nacional de Cancerología, Bogotá, Colombia
References
International Atomic Energy Agency A Guide to Clinical PET in Oncology: Improving Clinical Management of Cancer Patient s. Viena: IAEA; 2008.
Taïeb D, Neumann H, Rubello D, Al-Nahhas A, Guillet B, Hindié E. Modern nuclear imaging for paragangliomas: beyond SPECT. J Nucl Med. 2012;53:264-74.
https://doi.org/10.2967/jnumed.111.098152
Cuccurullo V, Mansi L. Toward tailored medicine (and beyond): the phaeochromocytoma and paraganglioma model. Eur J Nucl Med Mol Imaging. 2012;39:1262-5.
https://doi.org/10.1007/s00259-012-2156-2
Taïeb D, Rubello D, Al-Nahhas A, Calzada M, Marzola MC, Hindié E. Modern PET imaging for paragangliomas: relation to genetic mutations.EurJSurgOncol.2011;37:662-8.
https://doi.org/10.1016/j.ejso.2011.05.004
Timmers HJ, Kozupa A, Chen CC, Carrasquillo JA, Ling A, Eisenhofer G, et al. Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma. J Clin Oncol. 2007; 25: 2262-9.
https://doi.org/10.1200/JCO.2006.09.6297
Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K. The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas. 2010;39:775-83.
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Todos los derechos reservados.
