Influence of breast reconstructive complications surgery on the systemic treatment of breast cancer

Authors

Sandra Díaz Instituto Nacional de Cancerología
Ricardo Sánchez Instituto Nacional de Cancerología
Carlos Lehmann Instituto Nacional de Cancerología
Carlos Figueredo Instituto Nacional de Cancerología
Alejandro Duque Universidad Nacional de Colombia
Ana Orduz Instituto Nacional de Cancerología
Fernando Perry Instituto Nacional de Cancerología
Maria Ramírez Instituto Nacional de Cancerología
Javier Ángel Instituto Nacional de Cancerología, Bogotá
Carlos Duarte Instituto Nacional de Cancerología
Óscar García Instituto Nacional de Cancerología
Mauricio García Instituto Nacional de Cancerología
Luis Guzmán Instituto Nacional de Cancerología

Keywords:

Breast neoplasms, Complications, Breast reconstruction

Abstract Authors References How to Cite

Abstract

Objective: To establish the type of post surgical complications in patients with cancer and other tumors, taken to immediate or delayed mastectomy and breast cancer reconstruction over a decade in the National Cancer Institute (NCI); also, it’s association with the late start of adjuvant therapy and the relationship between neoadjuvant chemotherapy and the presence of complications.
Materials and methods: A review of the medical records of patients diagnosed with breast cancer, sarcoma, or phillodes breast tumor that were performed immediate or delayed mastectomy and breast reconstruction over the years 1998 to 2008.
Results: 342 patients were identified. 76% of those with locally advanced breast carcinoma. 60.53% of patients had some form of early local complication. Immediate reconstruction showed a greater percentage of complication (63% vs 49%); 67.5% of the patients from this series received neoadjuvant chemotherapy and of those, 135 (60%) presented an early local complication.
The rate of adjuvant treatments started in relation to the presence or absence of local complications was 26.12 adjuvants started by 100 patients/month (IC95%: 22.2 to 30.7) in patients with early local complications vs 55.06 adjuvants started by 100 patients/month (IC95%: 45.08 to 67.23) in patients with no local complications (log-rank test, p = 0.0079).
Conclusions: The neoadjuvant chemotherapy increases de risk of postoperative complications in patients with breast cancer undergoing mastectomy and immediate breast reconstruction. As the presence of early local complications delay the onset of adjuvant chemotherapy.

Author Biographies

Sandra Díaz, Instituto Nacional de Cancerología

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

Ricardo Sánchez, Instituto Nacional de Cancerología

Subdirección de Investigaciones, Instituto Nacional de Cancerología, Bogotá D.C., Colombia
Universidad Nacional de Colombia, Bogotá D.C., Colombia

Carlos Figueredo, Instituto Nacional de Cancerología

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

Alejandro Duque, Universidad Nacional de Colombia

Universidad Nacional de Colombia, Bogotá D.C., Colombia

Ana Orduz, Instituto Nacional de Cancerología

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

Fernando Perry, Instituto Nacional de Cancerología

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

Maria Ramírez, Instituto Nacional de Cancerología

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

Javier Ángel, Instituto Nacional de Cancerología, Bogotá

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

Carlos Duarte, Instituto Nacional de Cancerología

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

Óscar García, Instituto Nacional de Cancerología

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

Mauricio García, Instituto Nacional de Cancerología

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

Luis Guzmán, Instituto Nacional de Cancerología

Clínica de seno, Instituto Nacional de Cancerología, Bogotá D.C., Colombia

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How to Cite

[1]

Díaz S. et al. 2014. Influence of breast reconstructive complications surgery on the systemic treatment of breast cancer. Revista Colombiana de Cancerología. 18, 3 (Sep. 2014), 120–127.

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Published

2014-09-01

Issue

Vol. 18 No. 3 (2014)

Section

Research/original articles

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