Chemotherapy medication errors

Authors

  • José Alexander Carreño Dueñas Instituto Nacional de Cancerología
  • Jesús Oswaldo Sánchez Instituto Nacional de Cancerología
  • Carlos Daniel Bermúdez Silva Instituto Nacional de Cancerología
  • Mauricio Mesa Instituto Nacional de Cancerología

Keywords:

Medication errors, Hospital Oncology Department, Oncology pharmaceutical care, Chemotherapy

Abstract

Objectives: To describe and classify the medication errors that occurred during a 6 months period in oncology, hematology and pediatrics.
Methods: A cross-sectional study was conducted using a 6 month time period sample. The formulations selected were evaluated and classified according to error type, and the existence of patient-related effects were verified in the clinical notes.
Findings: A total of 440 formulations were reviewed and 54 errors (12.3%) were identified, with the most frequent being related to prescription. The severity of these errors was potentially harmful. A total of 17 adverse events were identified in patients, and were not associated with deaths or disabilities. Cyclophosphamide, trastuzumab, dexamethasone, among others, were associated with most errors.
Discussion: The overall error rate found is comparable with those in the world literature. Despite the complexity of the prescription, these errors remain avoidable, but a prevention program is needed that focuses on educational activities with participation by specialists, pharmaceutical chemists, nurses, as well as patients.

Author Biographies

José Alexander Carreño Dueñas, Instituto Nacional de Cancerología

Grupo de Investigación Clínica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia

Jesús Oswaldo Sánchez, Instituto Nacional de Cancerología

Grupo de Oncología clínica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia

Carlos Daniel Bermúdez Silva, Instituto Nacional de Cancerología

Grupo de Hematología, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia

Mauricio Mesa, Instituto Nacional de Cancerología

Grupo de Pediatría Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia

References

The National Coordinating Council for Medication Error Reporting and Prevention NCC MERP. Defining the Problem and Developing Solutions. 2005:1-40.

World Health Organization. Adherence to long-term therapies: evidence for action; 2003. p. 198.

Cohen MR, Anderson RW, Attilio RM, Green L, Muller RJ, Pruemer JM. Preventing medication errors in cancer chemotherapy. Am J Heal Syst Pharm. 1996;53:737-46.

https://doi.org/10.1093/ajhp/53.7.737

American Society of Hospital Pharmacists. ASHP guidelines on preventing medication errors in hospitals. Am J Hosp Pharm. 1993;50:305-14.

https://doi.org/10.1093/ajhp/50.2.305

Sánchez-Gómez E, Fernández-Lisón LC, Giménez-Castellanos J, Martín-Fernández N, Marín-Ariza I, Ynfante-Milá JI. Evaluación de errores en prescripciones antineoplásicas. Seguim Farmacoter. 2003;1:105-9.

Lambert BL, Lin SJ, Chang KY, Gandhi SK. Similarity as a risk factor in drug-name confusion errors: the look-alike (orthographic) and sound-alike (phonetic) model. Med Care. 1999;37:1214-25.

https://doi.org/10.1097/00005650-199912000-00005

The Joint Commission. Look-Alike, Sound-Alike Medication Names Patient Safety Solutions; 2007. p.1-4.

Thomas EJ, Studdert DM, Burstin HR, Orav EJ, Zeena T, Williams EJ, et al. Incidence and types of adverse events and negligent care in Utah and Colorado. Med Care. 2000;38:261-71.

https://doi.org/10.1097/00005650-200003000-00003

Slama C, Jerome J, Jacquot C, Bonan B. Prescription errors with cytotoxic drugs and the inadequacy of existing classifications. Pharm World Sci. 2005;27:339-43.

https://doi.org/10.1007/s11096-005-6034-x

Ranchon F, Salles G, Späth H-M, Schwiertz V, Vantard N, Parat S, et al. Chemotherapeutic errors in hospitalised cancer patients: attributable damage and extra costs. BMC Cancer [Internet]. BioMed Central Ltd. 2011;11:478.

https://doi.org/10.1186/1471-2407-11-478

Jaehde U, Liekweg A, Simons S, Westfeld M. Minimising treatment-associated risks in systemic cancer therapy. Pharm World Sci. 2008;30:161-8.

https://doi.org/10.1007/s11096-007-9157-4

Joerger M, Schellens JH, Beijnen JH. Therapeutic drug monitoring of non-anticancer drugs in cancer patients. Methods Find Exp Clin Pharmacol. 2004;26:531-45.

https://doi.org/10.1358/mf.2004.26.7.863736

Phillips J, Beam S, Brinker A, Holquist C, Honig P, Lee LY, et al. Retrospective analysis of mortalities associated with medication errors. Am J Heal Syst Pharm. 2001;58:1835-41.

https://doi.org/10.1093/ajhp/58.19.1835

Beijnen JH, Schellens JH. Drug interactions in oncology. Lancet Oncol. 2004;5:489-96.

https://doi.org/10.1016/S1470-2045(04)01528-1

Sano HS, Waddell JA, Solimando Jr DA, Doulaveris P, Myhand R. Study of the effect of standardized chemotherapy order forms on prescribing errors and anti-emetic cost. J Oncol Pharm Pract. 2005;11:21-30.

https://doi.org/10.1191/1078155205jp149oa

Bonnabry P, Cingria L, Ackermann M, Sadeghipour F, Bigler L, Mach N. Use of a prospective risk analysis method to improve the safety of the cancer chemotherapy process. Int J Qual Health Care. 2006;18:9-16.

https://doi.org/10.1093/intqhc/mzi082

How to Cite

[1]
Carreño Dueñas, J.A. et al. 2014. Chemotherapy medication errors. Revista Colombiana de Cancerología. 18, 4 (Dec. 2014), 179–185.

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Published

2014-12-01

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Section

Research/original articles