Breast amphicrine carcinoma. Report of an unusual case

Authors

  • Camilo Andrés Silva Barbosa Instituto Nacional de Cancerología
  • María Camila Álzate Meza Universidad de Manizales
  • Oscar Alberto Messa Botero Instituto Nacional de Cancerología
  • Sandra Isabel Chinchilla Olaya Instituto Nacional de Cancerología
  • Alfredo Ernesto Romero Rojas Instituto Nacional de Cancerología

Keywords:

Amphicrine tumor, Breast carcinoma, Chromogranin A, Synaptophysin, Adenoneuroendocrine
Abstract Authors References How to Cite

Abstract

Amphicrine tumours of the mammary gland are very rare dual lesions with epithelial and neuroendocrine differentiation in the same cell. We report the case of a woman with a mass in the right breast. The histopathology study showed a malignant tumour formed by small cells inter-mixed with some cells with a signet ring appearance. The use of antibodies showed immunoreactivity for epithelial and neuroendocrine markers in the malignant cells. These characteristics enable the diagnosis of an amphicrine tumour, based on the expression of epithelial and neuroendocrine markers in the same cell. The differential diagnosis must be made with collision tumours or with metastasis. The rigorous interpretation of the immunohistochemistry in the malignant cells in an amphicrine tumour is useful in order to distinguish this tumour from other diseases with similar morphological characteristics.

Author Biographies

Camilo Andrés Silva Barbosa, Instituto Nacional de Cancerología

Patología, Universidad Militar Nueva Granada- Programa Instituto Nacional de Cancerología, Bogotá D. C., Colombia

María Camila Álzate Meza, Universidad de Manizales

Facultad de Medicina, Universidad de Manizales, Manizales, Colombia

Oscar Alberto Messa Botero, Instituto Nacional de Cancerología

Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D. C., Colombia

Sandra Isabel Chinchilla Olaya, Instituto Nacional de Cancerología

Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D. C., Colombia

Alfredo Ernesto Romero Rojas, Instituto Nacional de Cancerología

Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá D. C., Colombia

Grupo Tumores Neuroendocrinos, Instituto Nacional de Cancerología, Bogotá D. C., Colombia

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How to Cite

[1]
Silva Barbosa, C.A. et al. 2015. Breast amphicrine carcinoma. Report of an unusual case. Revista Colombiana de Cancerología. 19, 3 (Sep. 2015), 173–179.

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Published

2015-09-01

Issue

Vol. 19 No. 3 (2015)

Section

Review articles

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