Photodynamic therapy for treatment of potentially malignant oral lesions
Keywords:
Photodynamic therapy, Leucoplakia, Lichen planus, Actinic cheilitisAbstract
Photodynamic therapy (PDT) is a topical, non-invasive and selective method for
potentially malignant oral lesions. The aim of this article is to present a literature review of the scientific evidence for the use of photodynamic therapy (PDT) in the treatment of these oral lesions.
A literature search was conducted in PubMed, limiting the search to the last 20 years. Finally, 24 articles including studies and case reports were selected.
Using different light sources for the activation of the photosensitising agent accumulated in the cells to treat, practically all of the studies reviewed showed good clinical and aesthetic results, with minor adverse effects (pain) and with reductions in both incidence and severity of the oral lesions found.
Author Biographies
Ana Cristina Vinals Narvaez, Universidad Complutense
Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontología, Universidad Complutense, Madrid, España
Marta Munoz Corcuera, Universidad Complutense
Departamento de Medicina y Cirugía Bucofacial, Facultad de Odontología, Universidad Complutense, Madrid, España
References
Saini R, Poh CF. Photodynamic therapy: a review and its prospective role in the management of oral potentially malignant disorders. Oral Dis. 2013;19:440-51.
https://doi.org/10.1111/odi.12003
Calzavara-Pinton P, Venturini M, Sala R. Photodynamic therapy: Update 2006. Part 1: Photochemistry and photobiology. J Eur Acad Dermatol Venereol. 2007;21:293-302.
https://doi.org/10.1111/j.1468-3083.2006.01902.x
Gupta AK, Ryder JE. Photodynamic therapy and topical aminolevulinic acid: An overview. Am J Clin Dermatol. 2003;4:699-708.
https://doi.org/10.2165/00128071-200304100-00004
Alexiades-Armenakas M. Laser-mediated photodynamic therapy. Clin Dermatol. 2006;24:16-25.
https://doi.org/10.1016/j.clindermatol.2005.10.027
Zhu TC, Finlay JC. The role of photodynamic therapy (PDT) physics. Med Phys. 2008;35:3127-36.
https://doi.org/10.1118/1.2937440
Calzavara-Pinton P, Venturini M, Sala R. Photodynamic therapy: Update 2006. part 2: Clinical results. J Eur Acad Dermatol Venereol. 2007;21:439-51.
https://doi.org/10.1111/j.1468-3083.2006.02038.x
Gursoy H, Ozcakir-Tomruk C, Tanalp J, Yilmaz S. Photodynamic therapy in dentistry: A literature review. Clin Oral Investig. 2013;17:1113-25.
https://doi.org/10.1007/s00784-012-0845-7
Ibbotson SH. Adverse effects of topical photodynamic therapy. Photodermatol Photoimmunol Photomed. 2011;27:116-30.
https://doi.org/10.1111/j.1600-0781.2010.00560.x
Jerjes W, Hamdoon Z, Hopper C. Photodynamic therapy in the management of potentially malignant and malignant oral disorders. Head Neck Oncol. 2012;4:16.
https://doi.org/10.1186/1758-3284-4-16
Aghahosseini F, Arbabi-Kalati F, Fashtami LA, Fateh M, Djavid GE. Treatment of oral lichen planus with photodynamic therapy mediated methylene blue: A case report. Med Oral Patol Oral Cir Bucal. 2006;11:E126-9.
Aghahosseini F, Arbabi-Kalati F, Fashtami LA, Djavid GE, Fateh M, Beitollahi JM. Methylene blue-mediated photodynamic therapy: A possible alternative treatment for oral lichen planus. Lasers Surg Med. 2006;38:33-8.
https://doi.org/10.1002/lsm.20278
Sadaksharam J, Nayaki KPT, Selvam NP. Treatment of oral lichen planus with methylene blue mediated photodynamic therapy-a clinical study. Photodermatol Photoimmunol Photomed. 2012;28:97-101.
https://doi.org/10.1111/j.1600-0781.2012.00647.x
Sobaniec S, Bernaczyk P, Pietruski J, Cholewa M, Skurska A, Doli'nska E, et al. Clinical assessment of the efficacy of photodynamic therapy in the treatment of oral lichen planus. Lasers Med Sci. 2013;28:311-6.
https://doi.org/10.1007/s10103-012-1153-9
Kvaal SI, Angell-Petersen E, Warloe T. Photodynamic treatment of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115:62-70.
https://doi.org/10.1016/j.oooo.2012.08.448
Kübler A, Haase T, Rheinwald M, Barth T, Mühling J. Treatment of oral leukoplakia by topical application of 5-aminolevulinic acid. Int J Oral Maxillofac Surg. 1998;27:466-9.
https://doi.org/10.1016/S0901-5027(98)80040-4
Sieron A, Adamek M, Kawczyk-Krupka A, Mazur S, Ilewicz L. Photodynamic therapy (PDT) using topically applied deltaaminolevulinic acid (ALA) for the treatment of oral leukoplakia. J Oral Pathol Med. 2003;32:330-6.
https://doi.org/10.1034/j.1600-0714.2003.00068.x
Chen H, Yu C, Tu P, Yeh C, Tsai T, Chiang C. Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy. Lasers Surg Med. 2005;37:114-22.
https://doi.org/10.1002/lsm.20214
Yu C, Lin H, Chen H, Yang H, Wang Y, Chiang C. Comparison of clinical outcomes of oral erythroleukoplakia treated with photodynamic therapy using either light-emitting diode or laser light. Lasers Surg Med. 2009;41:628-33.
https://doi.org/10.1002/lsm.20841
Shafirstein G, Friedman A, Siegel E, Moreno M, Bäumler W, Fan CY, et al. Using 5-aminolevulinic acid and pulsed dye laser for photodynamic treatment of oral leukoplakia. Arch Otolaryngol Head Neck Surg. 2011;137:1117-23.
https://doi.org/10.1001/archoto.2011.178
Kawczyk-Krupka A, Waskowska J, Raczkowska-Siostrzonek A, Ko'sciarz-Grzesiok A, Kwiatek S, Straszak D, et al. Comparison of cryotherapy and photodynamic therapy in treatment of oral leukoplakia. Photodiagnosis Photodyn Ther. 2012;9:148-55.
https://doi.org/10.1016/j.pdpdt.2011.12.007
Pietruska M, Sobaniec S, Bernaczyk P, Cholewa M, Pietruski JK, Doli'nska E, et al. Clinical evaluation of photodynamic therapy efficacy in the treatment of oral leukoplakia. Photodiagnosis Photodyn Ther. 2014;11:34-40.
https://doi.org/10.1016/j.pdpdt.2013.10.003
Wong SJ, Campbell B, Massey B, Lynch DP, Cohen EE, Blair E, et al. A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia. Oral Oncol. 2013;49:970-6.
https://doi.org/10.1016/j.oraloncology.2013.05.011
Berking C, Herzinger T, Flaig MJ, Brenner M, Borelli C, Degitz K. The efficacy of photodynamic therapy in actinic cheilitis of the lower lip: A prospective study of 15 patients. Dermatol Surg.2007;33:825-30.
https://doi.org/10.1097/00042728-200707000-00007
Kodama M, Watanabe D, Akita Y, Tamada Y, Matsumoto Y. Photodynamic therapy for the treatment of actinic cheilitis. Photodermatol Photoimmunol Photomed. 2007;23:209-10.
https://doi.org/10.1111/j.1600-0781.2007.00299.x
Sotiriou E, Apalla Z, Koussidou-Erremonti T, Ioannides D. Actinic cheilitis treated with one cycle of 5-aminolaevulinic acid-based photodynamic therapy: Report of 10 cases. Br J Dermatol. 2008;159:261-2.
https://doi.org/10.1111/j.1365-2133.2008.08607.x
Rossi R, Assad GB, Buggiani G, Lotti T. Photodynamic therapy: Treatment of choice for actinic cheilitis? Dermatol Ther. 2008;21:412-5.
https://doi.org/10.1111/j.1529-8019.2008.00224.x
Sotiriou E, Apalla Z, Chovarda E, Panagiotidou D, Ioannides D. Photodynamic therapy with 5-aminolevulinic acid in actinic cheilitis: An 18-month clinical and histological follow-up. J Eur Acad Dermatol Venereol. 2010;24:916-20.
https://doi.org/10.1111/j.1468-3083.2009.03550.x
Zaiac M, Clement A. Treatment of actinic cheilitis by photodynamic therapy with 5-aminolevulinic acid and blue light activation. J Drugs Dermatol. 2011;10:1240-5.
Ribeiro CF, Souza FH, Jordão JM, Haendchen LC, Mesquita L, Schmitt JV, et al. Photodynamic therapy in actinic cheilitis: Clinical and anatomopathological evaluation of 19 patients. An Bras Dermatol. 2012;87:418-23.
https://doi.org/10.1590/S0365-05962012000300011
Levi A, Wulf HC, Enk CD. Two cases of actinic cheilitis responsive to daylight-activated photodynamic therapy (DA-PDT). Photodermatol Photoimmunol Photomed. 2013;29:268-71.
https://doi.org/10.1111/phpp.12057
Casta˜no E, Comunión A, Arias D, Mi˜nano R, Romero A, Borbujo J. [Photodynamic therapy for actinic cheilitis]. Actas Dermosifiliogr. 2009;100:895-8.
https://doi.org/10.1016/S1578-2190(09)70561-X
Stender IM, Wulf HC. Photodynamic therapy with 5- aminolevulinic acid in the treatment of actinic cheilitis. Br J Dermatol. 1996;135:454-6.
https://doi.org/10.1111/j.1365-2133.1996.tb01513.x
Hauschild A, Lischner S, Lange-Asschenfeldt B, Egberts F. Treatment of actinic cheilitis using photodynamic therapy with methyl aminolevulinate: Report of three cases. Dermatol Surg. 2005;31:1344-7
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