Spinal cord compression due to nonleukemic granulocytic sarcoma
Keywords:
Leukemia myeloid, Sarcoma myeloid, Low back pain, Chemotherapy, RadiotherapyAbstract
Granulocytic sarcoma (GS) is an infrequent lesion associated with myelodysplastic or myeloproliferative disorders or leukemia, although it may be the first finding in an otherwise healthy patient. A case of GS is described that presented as spinal cord compression, in a patientwith no underlying hematological disorder. Imaging studies disclosed a single lytic lesion in L I, which required emergency surgery. Immunohistochemical staining of the surgical biopsy sam- pie was needed for diagnosis. Bone marrow aspirate was unremarkable. The patient received chemo-radiotherapy, dying 20 months after diagnosis of Pseudomonas aeruginosa sepsis during treatment of acute myelogenous leukemia. In short, primary GS is an infrequent and difficult to diagnose tumor. A high degree of suspicion, along with extensive immunohistochemical studies are necessary for diagnosis. Treatment should be prompt, aggressive and individualized, since the prognosis is very poor.
Author Biographies
Eduardo García Romo, Hospital Fundación Jiménez Díaz
Unidad de Cuidados Paliativos, Hospital Fundación Jiménez Díaz, Madrid, España
Eva Yebra Fernández, Hospital Universitario Severo Ochoa
Servicio de Hematología, Hospital Universitario Severo Ochoa, Leganés, Madrid, España
Ramón Rodríguez González, Hospital Universitario Severo Ochoa
bServicio de Hematología, Hospital Universitario Severo Ochoa, Leganés, Madrid, España
José Luís Agud Aparícío, Hospital Universitario Severo Ochoa
Servicio de Medicina Interna, Hospital Universitario Severo Ochoa, Leganés, Madrid, España
Rosalía Riaza Grau, Hospital Universitario Severo Ochoa
Servicio de Hematología, Hospital Universitario Severo Ochoa, Leganés, Madrid, España
Beatriz Valle Borrego, Hospital Universitario Severo Ochoa
Servicio de Urgencias, Hospital Universitario Severo Ochoa, Leganés, Madrid, España
Fernando Burgos Lázaro, Hospital Universitario Severo Ochoa
Servicio de Anatomía Patológica, Hospital Universitario Severo Ochoa, Leganés, Madrid, España
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