Hyponatraemia after cisplatin use: a case report
Keywords:
Chemotherapy, Cisplatin, Hyponatraemia, Inappropriate antidiuretic hormone secretion (IADHS), Renal salt wastingAbstract
The case is presented of a 26 year-old patient diagnosed with an immature teratoma of the right ovary. Tumour resection plus salpingo-oophorectomy was performed in June 2014. She received one cycle of adjuvant treatment with carboplatin and cyclophosphamide, but with no response. An exploratory laparotomy was performed due to an intestinal obstruction, which showed a pelvic mass and peritoneal implants at hepatic level.
She was assessed in the oncology clinic of the Colombian National Institute (INC) in February 2015, and treatment with a platinol (cisplatin), etoposide, and bleomycin (PEB) scheme was started. She received the first cycle without complications, but the second cycle was delayed due to an infection in the abdominal wall. She started the treatment with a normal serum sodium, with a subsequent decrease with no changes in the rest of the electrolytes, kidney function, or acid-base status. The patient showed no neurological signs and was euvolaemic. A hyponatraemia study was performed, ending up making the diagnosis of inappropriate antidiuretic hormone secretion (IADHS). A water restriction and high sodium diet was indicated, with the subsequent gradual increase in the serum Na levels. The IADHS was considered secondary to the use of cisplatin.
Author Biographies
Alan Ovalle, Instituto Nacional de Cancerología
Departamento de Oncología Clínica, Instituto Nacional de Cancerología, Facultad de Medicina, Medicina Interna, Fundación Universitaria Juan N. Corpas, Bogotá, D. C., Colombia
Diego González, Instituto Nacional de Cancerología
Departamento de Oncología Clínica, Instituto Nacional de Cancerología, Facultad de Medicina, Oncología Clínica, Universidad del Bosque, Bogotá, D. C., Colombia
Carlos Bonilla, Instituto Nacional de Cancerología
Departamento de Oncología Clínica, Instituto Nacional de Cancerología, Facultad de Medicina, Oncología Clínica, Universidad del Bosque, Bogotá, D. C., Colombia
Ricardo Brugés, Instituto Nacional de Cancerología
Departamento de Oncología Clínica, Instituto Nacional de Cancerología, Facultad de Medicina, Oncología Clínica, Universidad del Bosque, Bogotá, D. C., Colombia
Catalina Rúa Marín, Universidad de Antioquia
Facultad de Medicina, Endocrinología, Universidad de Antioquia, Medellín, Colombia
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