Three simultaneous primary cancers: Case report and literature review
DOI:
https://doi.org/10.35509/01239015.213Keywords:
Second primary, Synchronous neoplasms, Multiple primary malignancyAbstract
The presence of a second or third primary cancer after the initial diagnosis of malignancy is an increasingly frequent event associated with the improved survival and monitoring of cancer patients worldwide. However, the presence of three simultaneous primary neoplasms remains a singular event. The case is presented of a 76-year-old woman with a neuroendocrine tumour of the small intestine, sigmoid colon adenocarcinoma, and a mucinous ovarian adenocarcinoma, simultaneously surgically managed. A literature review on the topic was also conducted.
Author Biographies
Helena Facundo, Instituto Nacional de Cancerología
Servicio Cirugía Gastrointestinal y Endoscopia Digestiva, Instituto Nacional de Cancerología, Bogotá D. C., Colombia
Ricardo Oliveros, Instituto Nacional de Cancerología
Servicio Cirugía Gastrointestinal y Endoscopia Digestiva, Instituto Nacional de Cancerología, Bogotá D. C., Colombia
Jorge Andrés Mesa, Instituto Nacional de Cancerología
Servicio Patología, Instituto Nacional de Cancerología, Bogotá D. C., Colombia
References
Billroth T. Die allgemeine chirurgische Pathologie and Therapie. En: Reimer G, editor. In 51 Vorlesungen - Ein Handbuch für Studierende and Ärzte. 14 ed. Berlin: Reimer; 1889. p. 908.
Soerjomataram I, Coebergh JW. Epidemiology of multiple primary cancers. En: Verma, M., Editor. Methods in Molecular Biology, Cancer Epidemiology, vol. 471. Totowa, New Jersey: Humana Press; 2009. p. 85-105.
https://doi.org/10.1007/978-1-59745-416-2_5
Howe HL, editor. A review of the definition for multiple primary cancers in the United States. Springfield (IL): North American Association of Central Cancer Registries; 2003.
Amer MH. Multiple neoplasms, single primaries, and patient survival. Cancer Manag Res. 2014;6:119-34.
https://doi.org/10.2147/CMAR.S57378
Németh Z, Czigner J, Iván L, Ujpál M, Barabás J, Szabó G. Quadruple cancer, including triple cancers in the head and neck region. Neoplasma. 2002;49:412-4.
Holmes FF, Cole PA. Three primary cancers in different organs. Oncology. 1975;32:53-7.
https://doi.org/10.1159/000225051
Mariotto AB, Rowland JH, Ries LA, Scoppa S, Feuer E. Multiple cancer prevalence: a growing challenge in long-term survivorship. Cancer Epidemiol Biomarkers Prev. 2007;16:566-71.
https://doi.org/10.1158/1055-9965.EPI-06-0782
Travis LB, Rabkin CS, Brown LM, Allan JM, Alter BP, Ambrosone CB, et al. Cancer survivorship-genetic susceptibility and second primary cancers: research strategies and recommendations. J Natl Cancer Inst. 2006;98:15-25.
https://doi.org/10.1093/jnci/djj001
Travis LB. The epidemiology of second primary cancers. Cancer Epidemiol Biomarkers Prev. 2006;15:2020-6.
https://doi.org/10.1158/1055-9965.EPI-06-0414
Gerdes B, Ziegler A, Ramaswamy A, Wild A, Langer P, Bartsch DK. Multiple primaries in pancreatic cancer patients: indicator of a genetic predisposition? Int J Epidemiol. 2000;29: 999-1003.
https://doi.org/10.1093/ije/29.6.999
Raymond JS, Hogue CJ. Multiple primary tumours in women following breast cancer, 1973-2000. Br J Cancer. 2006;94:1745-50.
https://doi.org/10.1038/sj.bjc.6603172
Berg JW. The incidence of multiple primary cancers. I. Development of further cancers in patients with lymphomas, leukemias, and myeloma. J Natl Cancer Inst. 1967;38:741-52.
Kurishima K, Satoh H, Homma S, Kagohashi K, Ishikawa H, Ohtsuka M, et al. Multiple primary malignancies in patients with lung cancer. Radiology and Oncology. 2005;39:49-53.
Ribeiro U Jr, Cecconello I, Safatle-Ribeiro AV, Zilberstein B, Pinotti HW. Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract. Arq Gastroenterol. 1999;36:195-200.
https://doi.org/10.1590/S0004-28031999000400006
Coyte A, Morrison DS, McLoone P. Second primary cancer risk-the impact of applying different definitions of multiple primaries: results from a retrospective population-based cancer registry study. BMC Cancer. 2014;14:272.
https://doi.org/10.1186/1471-2407-14-272
Ueno M, Muto T, Oya M, Ota H, Azekura K, Yamaguchi T. Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer. Int J Clin Oncol. 2010;8:162-7.
https://doi.org/10.1007/s10147-003-0322-z
Zubaidi A. Multiple primary cancers of the colon, rectum, and the thyroid gland. Saudi J Gastroenterol. 2008;14:202-5.
https://doi.org/10.4103/1319-3767.43277
Lee WS, Lee JN, Choi S, Jung M, Baek JH, Lee WK. Multiple primary malignancies involving colorectal cancer-clinical characteristics and prognosis with reference to surveillance. Langenbeck's Arc Surg. 2010;395:359-64.
https://doi.org/10.1007/s00423-009-0553-1
Salem A, Abu-Hijlih R, Abdelrahman F, Turfa R, Amarin R, Farah N, et al. Multiple primary malignancies: Analysis of 23 patients with at least three tumors. Journal of gastrointestinal cáncer. 2012;43:437-43.
https://doi.org/10.1007/s12029-011-9296-7
Dasgupta P, Youlden DR, Baade PD. Multiple primary cancers among colorectal cancer survivors in Queensland, Australia, 1996-2007. Cancer Causes Control. 2012;23:1387-98.
https://doi.org/10.1007/s10552-012-9990-1
Bittorf B, Kessler H, Merkel S, Brückl W, Wein A, Ballhausen WG, et al. Multiple primary malignancies: an epidemiological and pedigree analysis of 57 patients with at least three tumours. Eur J Surg Oncol (EJSO). 2001;27:302-13.
https://doi.org/10.1053/ejso.2001.1112
Kamp K, Damhuis RA, Feelders RA, de Herder WW. Occurrence of second primary malignancies in patients with neuroendocrine tumors of the digestive tract and pancreas. Endocr Relat Cancer. 2012;19:95-9.
https://doi.org/10.1530/ERC-11-0315
Amin S, Warner RR, Itzkowitz SH, Kim MK. The risk of metachronous cancers in patients with small-intestinal carcinoid tumors: a US population-based study. Endocr Relat Cancer. 2012;19:381-7.
https://doi.org/10.1530/ERC-11-0392
Kerhulas GT. Primary cancer at three sites. Calif Med. 1960;93:306-7.
Koutsopoulos AV, Dambaki KI, Datseris G, Giannikaki E, Froudarakis M, Stathopoulos E. A novel combination of multiple primary carcinomas: urinary bladder transitional cell carcinoma, prostate adenocarcinoma and small cell lung carcinoma-report of a case and review of the literature. World J Surg Oncol. 2005;3:51.
https://doi.org/10.1186/1477-7819-3-51
Demirci U, Cos¸kun U, Göc¸ün PU, Gurlek B, Saka B, Öztürk B, et al. Four different malignancies in one patient: a case report. Cases J. 2010;3:53.
https://doi.org/10.1186/1757-1626-3-53
Campos ME, Salazar AL, Cabral WL. A case of synchronous triple primary cancers of the kidney, colon and prostate. Applied Cancer Research. 2012;32:30-1.
Mukaiyama Y, Suzuki M, Morikawa T, Mori Y, Takeshima Y, Fujimura T, et al. Multiple primary malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a Japanese male patient: a case report. World J Surg Oncol. 2014;12:294.
https://doi.org/10.1186/1477-7819-12-294
Rastogi M, Singh S, Singh S, Gupta S, Dwivedi RC. Triple primary malignant neoplasms including breast, esophagus and base tongue in an elderly male: A case report. J Cancer Res Ther. 2014;10:1109-11.
https://doi.org/10.4103/0973-1482.144639
Zhao J, Tan Y, Wu Y, Zhao W, Wu J, Ji M, et al. A rare case of eight multiple primary malignant neoplasms in a female patient: A case report and review of the literature. Oncol letters. 2015;9:587-90.
https://doi.org/10.3892/ol.2014.2789
Angurana SL, Kapoor R, Kumar P, Khosla D, Kumar N, Sharma SC, et al. Quadruple malignancy in a single patient: a case report and comprehensive review of literature. J Cancer Res Ther. 2010;6:230-2.
https://doi.org/10.4103/0973-1482.65237
Ikeda Y, Tsukuda M, Ishitoya J, Arai Y, Matsuda H, Katori H, et al. Four cases of simultaneous triple primary cancers of the hypopharynx esophagus, and stomach. Otolaryngol Head Neck Surg. 2005;132:788-93.
https://doi.org/10.1016/j.otohns.2005.01.037
Takatori E, Shoji T, Miura Y, Takeuchi S, Uesugi N, Sugiyama T. Triple simultaneous primary invasive gynecological malignancies: A case report. Journal Obstet Gynaecol Res. 2014;40:627-31.
https://doi.org/10.1111/jog.12199
Umeshappa H, Chandrashekhar M, Shenoy AM, Dinesh GR. Triple simultaneous primary tumors of the head and neck: A rare case report. International Journal of Case Reports and Images (IJCRI). 2014;5:488-91.
https://doi.org/10.5348/ijcri-201485-CR-10396
Williamson CW, Paravati A, Ghassemi M, Lethert K, Hua P, Hartman P, et al. Five Simultaneous Primary Tumors in a Single Patient: A Case Report and Review of the Literature. Case Rep Oncol. 2015;8:432-8.
https://doi.org/10.1159/000440799
Testori A, Cioffi U, De Simone M, Bini F, Vaghi A, Lemos A, et al. Multiple primary synchronous malignant tumors. BMC Res Notes. 2015;8:730.
https://doi.org/10.1186/s13104-015-1724-5
Capaldo GR, Kunschner AJ, Amin RM. Multiple primary neoplasms. Ovarian carcinoid tumor, mucinous cystadenoma of low malignant potential tumor of left ovary, and adenocarcinoma of the colon. Arch Pathol Lab Med. 1996;120: 393-6.
Yasuoka H, Tsujimoto M, Ueda M, Kodama R, Iwahashi Y, Inagaki M, et al. Monoclonality of composite large-cell neuroendocrine carcinoma and invasive intestinal-type mucinous adenocarcinoma of the cervix: a case study. Int J Gynecol Pathol. 2013;32:416-20.
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Todos los derechos reservados.
