Case report: Prostate squamous cell carcinoma managed with an external intensity-modulated radiotherapy technique
DOI:
https://doi.org/10.35509/01239015.202Keywords:
Prostate cancer, Squamous cell carcinoma, Radiotherapy, IMRTAbstract
The incidence of squamous cell carcinoma of prostate is between 0.5-1% of all neoplastic lesions of this gland.
Due to their rarity, there are no protocolised recommendations on the management of these patients. A report is presented on a patient with this diagnosis treated at our institution, its outcome at two years of follow-up, and a review of the subject.
Case report: Male patient, 79 years old, diagnosed with invasive squamous cell carcinoma of the prostate. Staged as T4NxMx/IPSA 2.64/Gleason undeterminable.Work up studies were negative, and primaries from nearby organs were ruled out.
He was treated with radiotherapy as monotherapy and was scheduled for an intensitymodulated radiotherapy (IMRT) technique, initially to the pelvis at a radiotherapy dose of 46 Gy 2Gy daily (PTV 1), further reinforcing prostate and vesicles up to 56 Gy (1.1 PTV), and finally to 76 Gy to prostate (PTV 1,1,1).
With a follow-up of two years, lung lesions were found, which were biopsied and positive for squamous cell carcinoma.
Author Biographies
Rosalba Ospino-Peña, Instituto Nacional de Cancerología
Departamento de Oncología Radioterápica, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia
Eduardo Guerrero, Instituto Nacional de Cancerología
Departamento de Oncología Radioterápica, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia
Rodolfo Varela, Instituto Nacional de Cancerología
Departamento de Urología Oncológica, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia
Angie Ramírez Ramírez, Instituto Nacional de Cancerología
Departamento de Epidemiología, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia
David López-Daza, Instituto Nacional de Cancerología
Grupo de Investigación Clínica, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia
References
Masuda H, Yamada T, Nagahama K, Nagamatu HN. Primary squamous cell carcinoma of the prostate: A case report. Jpn J Urol Surg. 1992;5:519-21.
Imamura M, Nishiyama H, Ohmori K, Nishimura K. Squamous cell carcinoma of the prostate without evidence of recurrence 5 years after operation. Urol Int. 2000;65:122-4 [consulta el 26 de octubre de 2015].
https://doi.org/10.1159/000064853
Marks LB, Yorke ED, Jackson A, Ten Haken RK, Constine LS, Eisbruch A, et al. Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys. 2010;76 3 suppl:S10-9.
https://doi.org/10.1016/j.ijrobp.2009.07.1754
Garofalo M, MoughanJ, Hong T, Bendell J, Berger A, Lerma F. RTOG 0822: A Phase II Study of Preoperative (PREOP) Chemoradiotherapy (CRT) Utilizing IMRT in Combination with Capecitabine (C) and Oxaliplatin (O) for Patients with Locally Advanced Rectal Cancer. International Journal of Radiation Oncology Biology Physics. 2011;81:S3-4.
https://doi.org/10.1016/j.ijrobp.2011.06.008
Bracarda S, de Cobelli O, Greco C, Prayer-Galetti T, Valdagni R, Gatta G, et al. Cancer of the prostate. Crit Rev Oncol Hematol. 2005;56:379-96 [consulta el 25 de octubre de 2015].
https://doi.org/10.1016/j.critrevonc.2005.03.010
Moskovitz B, Munichor M, Bolkier M, Livne PM. Squamous Cell Carcinoma of the Prostate. Urol Int. 1993;51:181-3 [consulta el 25 de octubre de 2015].
https://doi.org/10.1159/000282540
Randolph TL, Amin MB, Ro JY, Ayala AG. Histologic variants of adenocarcinoma and other carcinomas of prostate: pathologic criteria and clinical significance. Mod Pathol. 1997;10:612-29 [consulta el 25 de octubre de 2015].
Okamoto T, Ogiu K, Sato M, Kaneko T, Suzuki Y, Tanji S, et al. Primary squamous cell carcinoma of the prostate: a case report. Hinyokika Kiyo. 1996;42:67-70 [consulta el 25 de octubre de 2015].
Ulloa SA, Iturregui JR, Amézquita M, Ortiz VN. Squamous cell carcinoma of the prostate: case report and review of literature. Bol Asoc Med P R. 1997;89(10-12):192-4 [consulta el 25 de octubre de 2015].
Sieracki JC. Epidermoid carcinoma of the human prostate: report of three cases. Lab Invest. 1955;4:232-40 [consulta el 25 de octubre de 2015].
Thompson GJ, Albers DD, Broders AC. Unusual carcinomas involving the prostate gland. J Urol. 1953;69:416-25 [consulta el 26 de octubre de 2015].
https://doi.org/10.1016/S0022-5347(17)68084-4
Mott LJ. Squamous cell carcinoma of the prostate: report of 2 cases and review of the literature. J Urol. 1979;121:833-5 [consulta el 26 de octubre de 2015].
https://doi.org/10.1016/S0022-5347(17)57013-5
Corder MP, Cicmil GA. Effective treatment of metastatic squamous cell carcinoma of the prostate with adriamycin. J Urol. 1976;115:222.
https://doi.org/10.1016/S0022-5347(17)59143-0
Majeed F, Javed TA, Khan AU, Koerber RK. Primary squamous cell carcinoma of the prostate: a novel chemotherapy regimen. J Urol. 2002;168:640 [consulta el 26 de octubre de 2015];.
https://doi.org/10.1097/00005392-200208000-00054
Malik RD, Dakwar G, Hardee ME, Sanfilippo NJ, Rosenkrantz AB, Taneja SS. Squamous cell carcinoma of the prostate. Rev Urol. 2011;13:56-60.
Munoz F, Franco P, Ciammella P, Clerico M, Giudici M, Filippi AR, et al. Squamous cell carcinoma of the prostate: long-term survival after combined chemo-radiation. Radiat Oncol. 2007;2:15 [consulta el 26 de octubre de 2015].
https://doi.org/10.1186/1748-717X-2-15
Okada E, Kamizaki H. Primary squamous cell carcinoma of the prostate. Int J Urol. 2000;7:347---50 [consulta el 26 de octubre de 2015].
https://doi.org/10.1046/j.1442-2042.2000.00204.x
Uchibayashi T, Hisazumi H, Hasegawa M, Shiba N, Muraishi Y, Tanaka T, et al. Squamous cell carcinoma of the prostate. Scand J Urol Nephrol. 1997;31:223-4 [consulta el 26 de octubre de 2015].
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