Quantification of cytokines and their relationship with the presence of bacteraemia in acute leukaemia and febrile neutropenia after chemotherapy
DOI:
https://doi.org/10.35509/01239015.193Keywords:
Cytokines, Neutropenia, Fever, Chemotherapy, Acute leukaemia, BacteraemiaAbstract
Objectives: To describe the properties of several cytokines and their relationship with the presence of bacteraemia by measuring interleukins 1β, 6, 8, 10, 12p70, and tumour necrosis factor (TNFα) at four different times in patients with acute leukaemia and febrile neutropenia.
Methods: Plasma samples were obtained on diagnosis of neutropenia, at the onset of fever, and at 24 hours and 48 hours thereafter. They were stored at -70◦ C and then thawed for processing by flow cytometry. Medians were used along with their corresponding dispersion measurements.
Results: There were no reports of death at discharge. The rate of positive blood cultures was 25%, which was similar to that reviewed in the literature, with predominance of the isolation of Gram negative bacteria. Interleukins 10 and 6 showed a higher percentage of variation during the time of fever on comparing the bacteraemia group with the non- bacteraemia group. IL1, IL12p70, and TNFα± showed serum levels below the detection limit of the test.
Conclusions: Cytokines could play a promising role in the monitoring of febrile neutropenic patients, given the potential association with the presence of bacteraemia, an outcome well known as a predictor of morbidity and mortality in this population. However, more studies with a larger population are required to define a clear recommendation in the management guidelines for febrile neutropenia after chemotherapy.
Author Biographies
Ana Madera Rojas, Universidad Nacional de Colombia
GREICAH (Grupo de Investigación en Enfermedades Infecciosas en Cáncer y Alteraciones Hematológicas), Facultad de Medicina, Universidad Nacional de Colombia, Bogotá D. C., Colombia
Sonia Cuervo Maldonado, Instituto Nacional de Cancerología E.S.E.
GREICAH (Grupo de Investigación en Enfermedades Infecciosas en Cáncer y Alteraciones Hematológicas), Facultad de Medicina, Universidad Nacional de Colombia, Grupo de Infectología, Instituto Nacional de Cancerología E.S.E.,Bogotá D. C., Colombia
Ricardo Sánchez, Instituto Nacional de Cancerología E.S.E.
GREICAH (Grupo de Investigación en Enfermedades Infecciosas en Cáncer y Alteraciones Hematológicas), Facultad de Medicina, Universidad Nacional de Colombia, Grupo de Infectología, Instituto Nacional de Cancerología E.S.E., Bogotá D. C., Colombia
Julio Gómez Rincón, Instituto Nacional de Cancerología E.S.E.
GREICAH (Grupo de Investigación en Enfermedades Infecciosas en Cáncer y Alteraciones Hematológicas), Grupo de Infectología, Instituto Nacional de Cancerología E.S.E., Bogotá D. C., Colombia
Carlos Bermúdez , Instituto Nacional de Cancerología E.S.E.
GREICAH (Grupo de Investigación en Enfermedades Infecciosas en Cáncer y Alteraciones Hematológicas),Grupo de Infectología, Instituto Nacional de Cancerología E.S.E., Bogotá D. C., Colombia
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