Leiomyosarcoma ovarian cancer: a rare tumour with aggressive behaviour
Keywords:
Leiomyosarcoma, Myocytes, OvarianAbstract
Leiomyosarcomas may originate in most of the organs developed outside the central nervous system. There are documented cases of leiomyosarcomas of intestinal, mesenteric, uterine, retroperitoneal, and of soft and vascular tissue origin. However, cases of primary ovarian leiomyosarcoma are extremely rare, with few cases reported in the international literature. Leiomyosarcomas are believed to be those that originate from the walls of existing vasculature in ovarian parenchyma, in the smooth muscle around the follicles, or from remnants of the Wolff duct. Most cases occur in post-menopausal patients, and have an unfavourable prognosis in the short term. The mainstay of treatment remains the complete tumour debulking, with negative surgical margins in order to reduce the potential for recurrence. The benefit of the use of adjuvant chemotherapy as part of treatment of this condition remains uncertain.
Author Biographies
Julian Yañez, Hospital Universitario Erasmo Meoz
Clínica Ginecología Oncológica, Hospital Universitario Erasmo Meoz, Cúcuta, Colombia
Angélica Duque, Instituto Nacional de Cancerología
Clínica Ginecología Oncológica, Instituto Nacional de Cancerología, Universidad Militar Nueva Granada, Bogotá D. C., Colombia
María Islena Beltrán, Instituto Nacional de Cancerología
Patología Oncológica, Instituto Nacional de cancerología, Bogotá D. C., Colombia
References
Inoue J, Gomibuchi H, Minoura S. A case of a primary ovarian leiomyosarcoma. J Obstet Gynaecol Res [Internet].2000;26:401-7. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/11152324
https://doi.org/10.1111/j.1447-0756.2000.tb01349.x
Arslan OS, Sumer C, Cihangiroglu G, Kanat Pektas M, Gungor T. A rare tumor of the female genital tract: Primary ovarian leiomyosarcoma. Arch Gynecol Obstet. 2011;283 SUPPL. 1:83-5.
https://doi.org/10.1007/s00404-010-1735-3
Kumar VJ. A rare presentation of primary leiomyosarcoma of ovary in a young woman. Ecancermedicalscience [Internet]. 2015;9:1-6. Disponible en: http://www.ecancer.org/journal/9/524-a-rare-presentation-of-primary-leiomyosarcoma-ofovary-in-a-young-woman.php
https://doi.org/10.3332/ecancer.2015.524
López Hidalgo JL, Olivar Buera M, Quesada Hurtado J, Barqueros Ramírez A, Rodríguez Zarauz R, Lome˜na Álvarez G, et al. Leiomiosarcoma bien diferenciado de ovario. Rev Esp Patol. 2004;37:295-9.
Bodner K, Bodner Adler B, Czerwenka K, Hudelist G, Kimberger O, Leodolter S, et al. Bcl-2 expression in a primary leiomyosarcoma of the ovary: a case report. Wien Klin Wochenschr. 2003;115(5-6):191-5.
https://doi.org/10.1007/BF03040309
Bouie SM, Cracchiolo B, Heller D. Epithelioid leiomyosarcoma of the ovary. Gynecol Oncol. 2005;97:697-9.
https://doi.org/10.1016/j.ygyno.2005.02.008
Divya NS, Srinivasamurthy V. Myxoid Leiomyosarcoma of Ovary-A Rare Case Report. J Clin Diagnostic Res [Internet]. 2014;8:10-2. Disponible en: http://jcdr.net/article_fulltext.asp?issn=0973-709x&year=2014&volume=8&issue=6&page=FD05&issn=0973-709x&id=4424
Tas¸kin S, Tas¸kin EA, Uzüm N, Atao˘glu O, Ortac¸ F. Primary ovarian leiomyosarcoma: a review of the clinical and immunohistochemical features of the rare tumor. Obstet Gynecol Surv [Internet]. 2007;62:480-6. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/17572920
https://doi.org/10.1097/01.ogx.0000268629.16151.71
Lerwill MF, Sung R, Oliva E, Prat J, Young RH. Smooth Muscle Tumors of the Ovary. Am J Surg Pathol. 2004;28:1436-51.
https://doi.org/10.1097/01.pas.0000141393.99300.d0
Tsuyoshi H, Yoshida Y, Kurokawa T, Kotsuji F. Diagnosis and management of leiomyosarcoma arising from ovarian vein: Case report and literature review. J Obstet Gynaecol Res. 2012;38:466-70.
https://doi.org/10.1111/j.1447-0756.2011.01725.x
Nasu M, Inoue J, Matsui M, Minoura S, Matsubara O. Ovarian leiomyosarcoma: An autopsy case report. Pathol Int. 2000;50:162-5.
https://doi.org/10.1046/j.1440-1827.2000.01020.x
Rivas G, Bonilla C, Rubiano J, Arango N. Primary Leiomyosarcoma of the Ovary: A Case Report. Case Reports in Clinical Medicine. 2014;3:192-6.
https://doi.org/10.4236/crcm.2014.34045
Hensley ML, Barrette BA, Baumann K, Gaffney D, Hamilton AL, Kim JW, et al. Gynecologic Cancer InterGroup (GCIG) Consensus Review: Uterine and Ovarian Leiomyosarcomas. Int J Gynecol Cancer [Internet]. 2014;24 9 Suppl 3:S61-6. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/25341583
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