Kinase inhibitors. A story that began more than 50 years ago

Nowell PC, Hungerford DA. A minute chromosome in human chronic granulocytic leukemia. Science. 1960;132:1197.

https://doi.org/10.1016/b978-012448510-5.50134-5

Rowley JD. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243:290.

https://doi.org/10.1038/243290a0

Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D. The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science. 1986;233:212.

https://doi.org/10.1126/science.3460176

O’Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, Cornelissen JJ, Fischer T, Hochhaus A, Hughes T, Lechner K, Nielsen JL, Rousselot P, Reiffers J, Saglio G, Shepherd J, Simonsson B, Gratwohl A, Goldman JM, Kantarjian H, Taylor K, Verhoef G, Bolton AE, Capdeville R, Druker BJ, IRIS Investigators. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348:994-1004.

https://doi.org/10.1056/nejmoa022457

Gonzalo Vásquez Palacio, Gloria Cecilia Ramirez, Carlos Muskus, José Domingo Torres, Carlos Alberto Aya. Detección de mutaciones en el dominio tirosina quinasa de BCR-ABL1 en pacientes colombianos con leucemia mieloide crónica LMC, resistentes al imatinib. Revista Colombiana de Cancerología Esta es la referencia del artículo que se va a publicar en la revista.

https://doi.org/10.1016/j.rccan.2018.02.001