MANAGEMENT OF PATIENTS WITH GERMINAL CELL TUMORS IN FIRST RELAPSE
DOI:
https://doi.org/10.35509/01239015.113Keywords:
testicular cancer, germ cell tumor, non-Seminomatous, relapse, treatmentAbstract
Germ cell tumors (GCT) are the most common malignant neoplasms affecting young men aged 15 to 35 years. The optimal therapy option for patients with recurrent disease is still poorly defined. Options include second-line chemotherapy regimens at conventional doses that combine cisplatin and ifosfamide, with vinblastine, etoposide or paclitaxel, or alternatively high-dose chemotherapy with stem cell support. As there is still no conclusive evidence from clinical trials, the indications for the use of high-dose chemotherapy remain unclear. Second relapse treatment options should be individualized according to the patient and his previous treatment. Surgical resection of residual masses after chemotherapy is a key element for successful therapy. Currently, patients in Venezuela who have relapses should receive treatment with any of the established regimens that are used at conventional doses in the second line. If the patient has economic resources, he should receive treatment in an oncology center with a multidisciplinary team having access to treatment with high dose chemotherapy and to oncologist surgeons who are experts in this area.
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