Diagnosis of neurolymphomatosis as a late complication of non-Hodgkin lymphoma through 18F-FDG PET-CT
DOI:
https://doi.org/10.35509/01239015.101Keywords:
Neurolymphomatosis, Oncological Pain, Non-Hodgkin's Lymphoma, Positron-Emission tomographyAbstract
Neurolinfomatosis (LN) is a strange condition, defined as Invasion of cranial nerves and peripheral nerve roots by leukemia or lymphoma. Most of the cases are caused by non-Hodgkin's lymphoma of B cells (BHL). The present paper aims to emphasize the importance of suspecting this entity in patients with NHL and neuropathic pain and the role of 18F-FDG PET-CT in the diagnosis. We present the case of a 63-year-old woman diagnosed with diffuse large B-cell lymphoma, who in her third chemotherapy session DA-EPOCH-R of neuropathic pain in the right upper limb, with a poor clinical outcome, due to worsening pain, contralateral limb involvement, seizures and peripheral facial paralysis.
References
Baehring JM, Damek D, Martin EC, Betensky RA, Hochberg FH. Neurolymphomatosis. Neuro Oncol. 2003;5(2):104-15.
Baehring JM, Batchelor TT. Diagnosis and management of neurolymphomatosis. Cancer J. 2012;8(5):463-8.
Avila JD, Vivar C. Neurolymphomatosis: A review of 82 cases (P5. 141). Neurology. 2017;88(16 supplement).
Kamiya-Matsuoka C, Shroff S, Gildersleeve K, Hormozdi B, Manning JT, Woodman KH. Neurolymphomatosis: a case series of clinical manifestations, treatments, and outcomes. J Neurol Sci. 2014;343(1-2):144-8.
Rosso SM, de Bruin HG, Wu KL, Van den Bent MJ. Diagnosis of neurolymphomatosis with FDG PET. Neurology. 2006;67(4):722-3.
Oztürk E, Arpaci F, Kocaoğlu M, Arslan N, Bulakbaşi N, Ozgüven M. Detection of widespread neurolymphomatosis with 18F-FDG PET. Eur J Nucl Med Mol Imaging. 2006;33(8):975-6.
Strobel K, Fisher K, Hany TF, Poryazova R, Hung Hans H. Sciatic nerve neurolymphomatosis-extent and therapy response assessment with PET/CT. Clin Nucl Med. 2007;32(8):646-8.
Grisariu S, Avni B, Batchelor TT, van den Bent MJ, Bokstein F, Schiff D, et al. Neurolymphomatosis: an International Primary CNS Lymphoma CollaborativeGroup report. Blood. 2010;115(24):5005-11.
Shree R, Goyal MK, Modi M, Gaspar BL, Radotra BD, Ahuja CK, et al. The diagnostic dilemma of neurolymphomatosis. J Clin Neurol. 2016;12(3):274-81.
Toledano M, Siddiqui MA, Thompson CA, Garza I, Pittock SJ. Teaching NeuroImages: diagnostic utility of FDG-PET in neurolymphomatosis. Neurology. 2013;81(1):e3.
Canh NX, Tan NV, Tung TT, Son NT, Maurea S. (18)F-FDG PET/CT in neurolymphomatosis: Report of 3 cases. Asia Oceania J Nucl Med Biol. 2014; 2(1):57-64.
Salm LP, Van der Hiel B, Stokkel MP. Neurolymphomatosis diagnosed by (18)F-FDG PET-CT. Clin Nucl Med. 2013;38(6):e261-2.
Sideras PA, Matthews J, Sakib SM, Ofikwu F, Spektor V. Neurolymphomatosis of the peripheral nervous system: a case report and review of the literature. Clin Imaging. 2016;40(6):1253-6.
Trevisan AC, Ribeiro FB, Itikawa EN, Alexandre LS, Pitella FA, Santos AC, et al. 18F-FDG PET/CT/MRI Fusion images showing cranial and peripheral nerve involvement in neurolymphomatosis. Indian J Nucl Med. 2017; 32(1):77-8.
Kinoshita H, Yamakado H, Kitano T, Kitamura A, Yamashita H, Miyamoto M, et al. Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases. J Neurol. 2016;263(9):1719-26.
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Todos los derechos reservados.
