Metástasis óseas: Avances en el entendimiento y actualización del manejo farmacológico
DOI:
https://doi.org/10.35509/01239015.944Palabras clave:
neoplasias óseas, metástasis de la neoplasia, fracturas espontáneas, antineoplásicos, conservadores de la densidad óseaResumen
El hueso es uno de los sitios de metástasis más comunes. Estudios post mortem muestran enfermedad metastásica ósea (EMO) detectable en la mayoría de los pacientes que mueren por cáncer. La EMO implica un aumento de la morbimortalidad de los pacientes con cáncer (especialmente para aquellos cánceres con mayor sobrevida, como los de mama y próstata) y exige recursos de salud considerables para su tratamiento. Estudios recientes demuestran avances significativos en el entendimiento de la fisiopatología y del microambiente de la entidad; igualmente, se han encontrado nuevos blancos moleculares terapéuticos que favorecen positivamente el pronóstico de los pacientes. Los nuevos esfuerzos están encaminados a la predicción y prevención de los eventos esqueléticos asociados al cáncer. En este artículo se presenta una revisión de la evidencia actual en cuanto a la fisiopatología y tratamiento de la enfermedad metastásica ósea.
Biografía del autor/a
Camilo Soto-Montoya, Unidad Funcional Ortopedia, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.
1. Unidad Funcional Ortopedia, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.
Luis Carlos Gómez-Mier, Unidad Funcional Ortopedia, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.
1. Unidad Funcional Ortopedia, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.
Andrea Franco-Betancur, Fellow, Posgrado Médico-Quirúrgico de Ortopedia Oncológica, Convenio Universidad Militar Nueva Granada - Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.
2. Fellow, Posgrado Médico-Quirúrgico de Ortopedia Oncológica, Convenio Universidad Militar Nueva Granada - Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.
Sergio Andrés Arroyave-Rivera, Fellow, Posgrado Médico-Quirúrgico de Ortopedia Oncológica, Convenio Universidad Militar Nueva Granada - Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.
2. Fellow, Posgrado Médico-Quirúrgico de Ortopedia Oncológica, Convenio Universidad Militar Nueva Granada - Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.
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