Clinical outcomes in patients with early non-small-cell lung cancer treated surgically in Bogotá (Colombia)
DOI:
https://doi.org/10.35509/01239015.904Keywords:
Carcinoma, non-small-cell lung, adenocarcinoma of lung, neoplasm staging, recurrenceAbstract
Introduction: In Colombia, information is limited on the survival of patients with lung cancer treated in the early stages. Thus, this study aimed to analyze the clinical outcomes and factors associated with the prognosis of patients with non-small-cell lung cancer (NSCLC) treated surgically in three institutions in Bogotá.
Methods: Analytical, observational, retrospective, and multicenter study.
Results: The study included 101 patients with a median age of 69 years (IQR 63-75); 56 were women (55.4%). Of the patients, 8 (7.9%) had pathological stage 0, 83 (82.2%) were in stage I and 10 (9.9%) in stage II. The 3-year disease-free survival (DFS) of patients with stages 0, I, and II was 100%, 97%, and 58%, respectively. The overall survival (OS) of all included patients at 3 years was 94%. The OS of patients with and without relapse was 78% and 96%. A statistically significant association was found between relapse and stage II (P<0.001), relapse and T3 (P=0.048), relapse and N1 (P<0.001), and relapse and visceral pleura invasion (P=0.002). The only association found with death was relapse (P=0.002).
Conclusions: The pathological stage and some special TNM characteristics, such as T3 tumor, the presence of N1 disease, and visceral pleura invasion, were determining factors in DFS. In contrast, the only factor associated with worse OS was relapse.
Author Biographies
Fernando Alvarado-Sarzosa, Fellow, Programa de Posgrado Cirugía de Tórax, Convenio Docencia-Servicio Universidad El Bosque-Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
1. Fellow, Programa de Posgrado Cirugía de Tórax, Convenio Docencia-Servicio Universidad El Bosque-Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
Stella Isabel Martínez-Jaramillo, Cirugía de Tórax, Clínica Reina Sofía, Bogotá, D.C., Colombia
2. Cirugía de Tórax, Clínica Reina Sofía, Bogotá, D.C., Colombia.
3. Docente, Programa de especialización en Cirugía de Tórax, Universidad El Bosque, Bogotá, D.C., Colombia.
Luis Gerardo García-Herreros-Hellal, Cirugía de Tórax, Fundación Santa Fe de Bogotá, Bogotá, D.C., Colombia.
4. Cirugía de Tórax, Fundación Santa Fe de Bogotá, Bogotá, D.C., Colombia.
Rafael José Beltrán-Jiménez5, Unidad Funcional Cirugía de Tórax, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
5. Unidad Funcional Cirugía de Tórax, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
Juan David Zuluaga-Restrepo, Cirugía de Tórax, Clínica CES, Medellín, Colombia.
6. Cirugía de Tórax, Clínica CES, Medellín, Colombia.
Rafael Parra-Medina, Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
7. Grupo Patología Oncológica, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
Laura Lucía Escobar-Ávila, Laboratorio de Patología, Clínica Reina Sofía, Bogotá, D.C., Colombia.
8. Laboratorio de Patología, Clínica Reina Sofía, Bogotá, D.C., Colombia.
José Daniel Toledo-Arenas, Psiquiatría y Epidemiología, Universidad El Bosque, Bogotá, D.C., Colombia.
9. Psiquiatría y Epidemiología, Universidad El Bosque, Bogotá, D.C., Colombia.
Carlos Andrés Carvajal-Fierro, Unidad Funcional Cirugía de Tórax, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
5. Unidad Funcional Cirugía de Tórax, Instituto Nacional de Cancerología, Bogotá, D.C., Colombia.
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