Transverse colon squamous cell cancer: Case report
DOI:
https://doi.org/10.35509/01239015.880Keywords:
colonic neoplasms, carcinoma, squamous cell, drug therapyAbstract
Only 12% of patients diagnosed with colorectal cancer are under 50 years of age, and 37% of these are rectal tumors. The most common histological form of colon cancer is adenocarcinoma. However, rare histologies can be found in the colon and rectum. Squamous cell carcinoma of the colon is a rare tumor with an estimated incidence of less than 1 per 100,000 patients affected by colorectal tumors. The localized disease does not have a standard treatment approach, but a combination of surgery and chemotherapy with or without (neo)adjuvant radiotherapy is proposed. We describe the clinical case of a young adult patient with no relevant medical history, diagnosed with transverse colon squamous cell cancer who underwent surgery achieving negative oncologic margins. The patient presented with relapse in the small intestine managed with chemotherapy and surgery with a complete response to treatment.
Author Biographies
Alicia Quiroga-Echeverri, Grupo de Oncología Clínica, Hospital Pablo Tobón Uribe, Medellín, Colombia.
1. Grupo de Oncología Clínica, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Luis Gabriel González-Pérez, Grupo de Oncología Clínica, Hospital Pablo Tobón Uribe, Medellín, Colombia.
1. Grupo de Oncología Clínica, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Isabel Cristina Durango, Grupo de Oncología Clínica, Hospital Pablo Tobón Uribe, Medellín, Colombia.
1. Grupo de Oncología Clínica, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Sergio Iván Hoyos, Grupo de Cirugía Hepatobiliar, Hospital Pablo Tobón Uribe, Medellín, Colombia.
2. Grupo de Cirugía Hepatobiliar, Hospital Pablo Tobón Uribe, Medellín, Colombia.
Ana María Arango Rivas, Medicina interna, Clínica AUNA, Medellín, Colombia.
3. Medicina interna, Clínica AUNA, Medellín, Colombia.
References
Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70(3):145-64. https://doi.org/10.3322/caac.21601
Dikshit V, Ali I, Patil C, Manerikar K, Mody P. Squamous cell carcinoma of colon-an etiopathological surprise. J Gastrointest Cancer. 2019;50(3):604-8. https://doi.org/10.1007/s12029-018-0072-9
Puga R, Ramia JM, de la Plaza R, Sabater C, García E. Carcinomas adenoescamosos y escamosos de colon y recto. Gastroenterol Hepatol. 2015; 38(4):283-5. https://doi.org/10.1016/j.gastrohep.2014.03.018
Okabayashi K, Hasegawa H, Ishii Y, Endo T, Kitagawa Y. Adenosquamous carcinoma of the sigmoid colon treated by the less invasive procedures of endoscopy and laparoscopy: report of a case. Surg Today. 2009;39(11):994-7. https://doi.org/10.1007/s00595-009-3961-5
Anagnostopoulos G, Sakorafas GH, Kostopoulos P, Grigoriadis K, Pavlakis G, Margantinis G, et al. Squamous cell carcinoma of the rectum: a case report and review of the literature. Eur J Cancer Care (Engl). 2005;14(1):70-4. https://doi.org/10.1111/j.1365-2354.2005.00523.x
Frizelle FA, Hobday KS, Batts KP, Nelson H. Adenosquamous and squamous carcinoma of the colon and upper rectum: a clinical and histopathologic study. Dis Colon Rectum. 2001;44(3):341-6. https://doi.org/10.1007/BF02234730
Dong Y, Wang J, Ma H, Zhou H, Lu G, Zhou X. Primary adenosquamous carcinoma of the colon: report of five cases. Surg Today. 2009;39(7):619-23. https://doi.org/10.1007/s00595-008-3884-6
Schizas D, Katsaros I, Mastoraki A, Karela NR, Zampetaki D, Lazaridis II, et al. Primary squamous cell carcinoma of colon and rectum: A systematic review of the literature. J Invest Surg. 2022;35(1):151-6. https://doi.org/10.1080/08941939.2020.1824044
Clark J, Cleator S, Goldin R, Lowdell C, Darzi A, Ziprin P. Treatment of primary rectal squamous cell carcinoma by primary chemoradiotherapy: should surgery still be considered a standard of care? Eur J Cancer. 2008;44(16):2340-3. https://doi.org/10.1016/j.ejca.2008.07.004
Shi J, Sun Y, Gao P, Song Y, Sun J, Chen X, et al. Basic characteristics and therapy regimens for colorectal squamous cell carcinoma. Translat Cancer Res. 2018;7(2):268-82. https://doi.org/10.21037/tcr.2018.03.04
Linardoutsos D, Frountzas M, Feakins RM, Patel NH, Simanskaite V, Patel H. Primary colonic squamous cell carcinoma: a case report and review of the literature. Ann R Coll Surg Engl. 2020;102(9):e1-e7. https://doi.org/10.1308/rcsann.2020.0149
Zhao S, Guo J, Sun L, Lv J, Qiu W. Gemcitabine-based chemotherapy in colon squamous cell carcinoma: A case report and literature review. Mol Clin Oncol. 2017;6(4):561-5. https://doi.org/10.3892/mco.2017.1178
How to Cite
Downloads
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Revista Colombiana de Cancerología
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Todos los derechos reservados.
