Aislamiento de exosomas a partir de biopsia líquida y su potencial aplicación en la clínica

Autores/as

DOI:

https://doi.org/10.35509/01239015.733

Palabras clave:

neoplasias, biopsia líquida, exosomas, biomarcadores de tumor, protocolos antineoplásicos

Resumen

Los exosomas son microvesículas extracelulares secretadas por las células que han cobrado gran importancia por su potencial aplicación en la clínica para la identificación de nuevos biomarcadores de diagnóstico, pronóstico y seguimiento de enfermedades como el cáncer, o para determinar su potencial aplicación terapéutica. Dado que estas vesículas se encuentran de forma natural en fluidos corporales tales como sangre, orina o saliva, es posible aislarlas a partir de una biopsia líquida para analizar su contenido, dilucidar su interacción con diferentes poblaciones celulares (crosstalk) y determinar su efecto durante el desarrollo de una patología particular. En esta revisión abordamos los últimos hallazgos relacionados con el diseño y la aplicación de terapias que emplean vesículas extracelulares, particularmente exosomas, para el tratamiento del cáncer o como biomarcadores de diagnóstico, pronóstico o seguimiento de la enfermedad.

Biografía del autor/a

Paula Morales, Semillero de Investigación en Inmunobiología Tumoral, Universidad Distrital Francisco José de Caldas (SIIT-UD), Bogotá, D. C., Colombia.

1. Semillero de Investigación en Inmunobiología Tumoral, Universidad Distrital Francisco José de Caldas (SIIT-UD), Bogotá, D. C., Colombia.

Nicolás Molina, Semillero de Investigación en Inmunobiología Tumoral, Universidad Distrital Francisco José de Caldas (SIIT-UD), Bogotá, D. C., Colombia.

1. Semillero de Investigación en Inmunobiología Tumoral, Universidad Distrital Francisco José de Caldas (SIIT-UD), Bogotá, D. C., Colombia.

Josefa Rodríguez , Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.

2. Grupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología, Bogotá, D. C., Colombia.

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Cómo citar

[1]
Morales Suárez, P.D. et al. 2022. Aislamiento de exosomas a partir de biopsia líquida y su potencial aplicación en la clínica. Revista Colombiana de Cancerología. 26, 2 (jun. 2022), 137–149. DOI:https://doi.org/10.35509/01239015.733.

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30-06-2022

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Datos de los fondos

  • Instituto Nacional de Cancerología
    Números de la subvención Proyecto “Utilidad clínica de la molécula HLA-G soluble en el diagnóstico y pronostico del Cáncer Gástrico” con código xRPM N° C19010300-408