Chlamydia trachomatis infections and their association with the human papilloma virus (HPV) in a cohort study
Keywords:
HPV, C. trachomatis, cohort studies, ColombiaAbstract
Objective: To study the natural course of C. trachomatis infections and their association with the human papilloma virus (HPV) in women with normal cytology, from Bogotá, during a 5-year period. Methodology: Eighty-two women who were positive for C. trachomatis at the start of the study were studied at 6-month intervals. At each visit, a cervical scrape was collected for C. trachomatis endogenous plasmid and HPV detection by PCR-EIA by using the specific primers Bio PL6.1/ PL6.2 y Bio GP5+/ GP6+, respectively.
Results: Among 82 positive women for C. trachomatis, 18 (21.9%) were positive for generic HPV, 13 (15.8%) of them infected with high-risk types, and 5 (6.1%) with low-risk types. The infection with generic HPV was not associated with an increased rate of C. trachomatis clearance (RR 0.96 Cl 0.6- 1.4). Likewise, high-risk (RR 0.92 Cl 0.5-1.5) and low-risk types (RR 0.95 Cl 0.5-1.7) were not associated with C. trachomatis clearance. After 4 years of follow-up, 6% of the women had not cleared the C trachomatis infection.
Conclusions: In this follow-up study, a low percent of C. trachomatis infections persists after 4 years of follow-up, and a clear association between HPV infections and C. trachomatis clearance was not observed.
Author Biographies
Mónica Molano, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología, Bogotá, D.C.,Colombia. Grupo de Investigación en la Biología del Cáncer.
Vrije Universiteit Medical Center, Amsterdam. The Netherlands Department of Pathology.
Chris Meijer, Vrije Universiteit Medical Center
Vrije Universiteit Medical Center, Amsterdam. The Netherlands Department of Pathology.
Héctor Posso, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología, Bogotá, D.C.,Colombia. Grupo de Investigación en la Biología del Cáncer.
Annie Arslan, International Agency for Research on Cancer
International Agency for Research on Cancer, Lyon, Francia. Unit of Field and Intervention Studies.
Nubia Muñoz, International Agency for Research on Cancer
International Agency for Research on Cancer, Lyon, Francia. Unit of Field and Intervention Studies.
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