CD20, generalidades básicas-moleculares y su posible relación como marcador de mal pronóstico en leucemia

Autores/as

  • Andrea Natali Bastidas-Sánchez Unidad Académica de Salud y Bienestar, Facultad de Bioquímica y Farmacia, Universidad Católica de Cuenca, Cuenca, Ecuador. https://orcid.org/0000-0002-6134-6449
  • Gabriele Davide Bigoni-Ordóñez Unidad Académica de Salud y Bienestar, Facultad de Bioquímica y Farmacia, Universidad Católica de Cuenca, Cuenca, Ecuador. https://orcid.org/0000-0003-2091-6107

DOI:

https://doi.org/10.35509/01239015.892

Palabras clave:

antígenos CD20, pronóstico, leucemia-linfoma linfoblástico de células precursoras, linfocitos B

Resumen

CD20 es una proteína transmembranal expresada en la superficie del linfocito B y desempeña un papel muy importante en su desarrollo y diferenciación. Se expresa en la gran mayoría de neoplasias de células B, como en la leucemia linfoblástica aguda (LLA). Se recopiló información sobre la estructura biológica y molecular del marcador CD20 y su mecanismo de regulación, para mejorar el entendimiento sobre su función dentro de la célula, el efecto que ejerce como marcador de mal pronóstico cuando se encuentra expresado en pacientes adultos diagnosticados con LLA y las ventajas de ser utilizado como blanco terapéutico en esta patología.

Biografía del autor/a

Andrea Natali Bastidas-Sánchez, Unidad Académica de Salud y Bienestar, Facultad de Bioquímica y Farmacia, Universidad Católica de Cuenca, Cuenca, Ecuador.

1. Unidad Académica de Salud y Bienestar, Facultad de Bioquímica y Farmacia, Universidad Católica de Cuenca, Cuenca, Ecuador.

Gabriele Davide Bigoni-Ordóñez, Unidad Académica de Salud y Bienestar, Facultad de Bioquímica y Farmacia, Universidad Católica de Cuenca, Cuenca, Ecuador.

1. Unidad Académica de Salud y Bienestar, Facultad de Bioquímica y Farmacia, Universidad Católica de Cuenca, Cuenca, Ecuador.

2. Facultad de Ciencias Médicas, Carrera de Laboratorio Clínico, Universidad de Cuenca, Cuenca, Ecuador.

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Bastidas Sánchez, A.N. y Bigoni Ordóñez, G.D. 2023. CD20, generalidades básicas-moleculares y su posible relación como marcador de mal pronóstico en leucemia. Revista Colombiana de Cancerología. 27, 1 (mar. 2023), 150–158. DOI:https://doi.org/10.35509/01239015.892.

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30-03-2023

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