Hematopoyesis Clonal de Potencial Indeterminado (HCPI): más allá de un modelo de campo de cancerización

Autores/as

  • Oscar Andres Franco Tavera Departamento de Patología. Universidad Nacional de Colombia, Bogotá. Colombia
  • Natalia Olaya Morales Departamento de Patología. Universidad Nacional de Colombia, Bogotá. Colombia

DOI:

https://doi.org/10.35509/01239015.726

Palabras clave:

Hematopoyesis clona, expansión clonal, campo de cancerización, quimioterapia, Neoplasia Mieloide asociada a terapia, mutación somática, inflamación, envejecimiento

Resumen

La Hematopoyesis Clonal de Potencial Indeterminado (HCPI) más conocido como CHIP por sus siglas en ingles se define como la expansión clonal de Células Madre Hematopoyéticas (CMHs) que albergan una o más mutaciones somáticas (en la mayoría de los casos una sola mutación) sin un cáncer hematológico subyacente ni evidencia morfológica definitiva de displasia, con una frecuencia alélica mayor al 2%. Los individuos con HCPI progresan a malignidad a una tasa de cerca del 0.5 a 1% por año, convirtiéndose así en un modelo de campo de cancerización. Sin embargo, sus implicaciones van más allá debido a que se ha encontrado asociación con enfermedades inflamatorias crónicas como enfermedad cardiovascular ateroesclerótica, diabetes y enfermedades autoinmunes. Además, es considerado un factor predictivo en pacientes con cáncer hematolológico y no hematológico que reciben quimioterapia y radioterapia. 

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Cómo citar

[1]
Franco Tavera, O.A. y Olaya Morales, N. 2021. Hematopoyesis Clonal de Potencial Indeterminado (HCPI): más allá de un modelo de campo de cancerización. Revista Colombiana de Cancerología. 25, 4 (dic. 2021), 210–221. DOI:https://doi.org/10.35509/01239015.726.

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06-05-2021 — Actualizado el 23-12-2021

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