Respuesta inmune humoral hacia los papilomavirus oncogénicos tipos 16, 31 y 58 en mujeres colombianas con citología normal
Palabras clave:
neoplasias del cuello uterino, papiloma, anticuerpos, historia naturalResumen
Objetivo: Caracterizar la respuesta IgG e IgA hacia VLP (partículas semejantes a virus) del virus del papiloma humano (VPH) 16, 31 y 58 y determinar su asociación con la eliminación de la infección.
Métodos: Se incluyeron 186 mujeres con citología normal participantes en un estudio de cohorte sobre la historia natural de la infección por VPH. Se evaluaron tres grupos: control (negativas para ADN VPH, n=146), eliminación (positivas al ingreso y negativas durante el seguimiento, n=25) y persistencia (positivas durante el seguimiento, n=15). Los anticuerpos IgG e IgA hacia VLP VPH 16, 31 y 58 se analizaron mediante ELISA.
Resultados: En la primera visita, se observó en el grupo de eliminación una mayor seroprevalencia de anticuerpos IgG hacia VLP VPH 16. Esta prevalencia estuvo acompañada de mayores niveles de anticuerpos en este grupo, en comparación con los niveles observados en el grupo de persistencia (media DO405 nm 0,665 vs. 0,290, respectivamente). En contraste, en la quinta visita, se observó una mayor seroprevalencia de anticuerpos IgG hacia VLP VPH 16 y 58 en el grupo de persistencia (p=0,001 y p=0,003, respectivamente). Esta respuesta se correlacionó con mayores niveles de anticuerpos en esta visita (media DO405 nm 0,653 y 0,532, respectivamente), en comparación con los niveles de anticuerpos observados en la primera visita (media DO405 nm 0,290 y 0,362, respectivamente).
Conclusiones: La presencia de altos niveles de anticuerpos IgG hacia VPH 16 y 58 durante la infección podría estar asociada con la eliminación de la infección.
Biografía del autor/a
Alba Lucía Cómbita, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología. Bogotá, Colombia.
Mónica Molano, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología. Bogotá, Colombia.
Nubia Muñoz, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología. Bogotá, Colombia.
María Mercedes Bravo, Instituto Nacional de Cancerología
Instituto Nacional de Cancerología. Bogotá, Colombia.
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