La biopsia líquida en el diagnóstico y monitoreo de pacientes oncológicos: oportunidades y retos en Latinoamérica

Autores/as

  • Sandra Perdomo Universidad El Bosque
  • Lorena Montealegre-Páez Universidad El Bosque
  • Rafael Pacheco-Orozco Universidad El Bosque
  • Héctor Martínez-Gregorio Laboratorio Nacional en Salud
  • Felipe Vaca-Paniagua Laboratorio Nacional en Salud
  • Javier Ardila Universidad Nacional de Colombia
  • Federico Cayol Hospital Italiano
  • Javier Oliver Hospitales Universitarios Regional y Virgen de la Victoria
  • Cecilia Frecha Consejo Superior de Investigaciones Cientificas y Técnicas
  • Javier López Clínica Colsanitas S.A
  • David Carreño Clínica Colsanitas S.A

DOI:

https://doi.org/10.35509/01239015.44

Palabras clave:

Biopsia Líquida, América Latina, Ácidos Nucleicos Libres de Células, Terapia Molecular Dirigida

Resumen

En los últimos años, el estudio de los ácidos nucleicos circulantes ha tenido grandes avances en el campo de la oncología, lo que ha permitido avanzar de forma importante en las aplicaciones clínicas de la biopsia liquida en diferentes aspectos como el pronóstico, la estadificación, la predicción de recurrencia, la selección y monitorización de tratamientos, entre otros. Lo anterior, se debe en gran parte al desarrollo de nuevas y mejores tecnologías, algunas de las cuales, incluso, han sido autorizadas para el diagnóstico y seguimiento de ciertos tipos de cáncer. No obstante, la utilización de biopsias líquidas sigue siendo objeto de estudio, pues a pesar de que son evidentes sus ventajas aun existen ciertas limitaciones que deben ser objeto de futuras investigaciones. Por lo tanto, debido a la importancia que ha cobrado este avance tecnológico a nivel mundial, se realizó una revisión de literatura con el fin de establecer el estado actual de la biopsia liquida en oncología, así como sus aplicaciones clínicas actuales, no sólo a nivel mundial sino también en Latinoamérica.

Biografía del autor/a

Sandra Perdomo, Universidad El Bosque

Instituto de Investigación en Nutrición, Genética y Metabolismo, Facultad de Medicina. Universidad El Bosque. Bogotá, Colombia.

Departamento de Patología y Laboratorios, Hospital Universitario Fundación Santafé de Bogotá

Lorena Montealegre-Páez, Universidad El Bosque

Instituto de Investigación en Nutrición, Genética y Metabolismo, Facultad de Medicina. Universidad El Bosque. Bogotá, Colombia.

Rafael Pacheco-Orozco, Universidad El Bosque

Instituto de Investigación en Nutrición, Genética y Metabolismo, Facultad de Medicina. Universidad El Bosque. Bogotá, Colombia.

Héctor Martínez-Gregorio, Laboratorio Nacional en Salud

Laboratorio Nacional en Salud: Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-Degenerativas, Facultad de Estudios Superiores Iztacala. Tlalnepantla, Estado de México, México.

Felipe Vaca-Paniagua, Laboratorio Nacional en Salud

Laboratorio Nacional en Salud: Diagnóstico Molecular y Efecto Ambiental en Enfermedades Crónico-Degenerativas, Facultad de Estudios Superiores Iztacala. Tlalnepantla, Estado de México, México.

Subdirección de Investigación Básica, Insituto Nacional de Cancerología. México

Javier Ardila, Universidad Nacional de Colombia

Instituto de Genética Humana, Universidad Nacional de Colombia. Bogotá, Colombia

Federico Cayol, Hospital Italiano

Hospital Italiano, Sección de Oncología. Buenos Aires, Argentina.

Javier Oliver, Hospitales Universitarios Regional y Virgen de la Victoria

Servicio de Oncologia Médica, Hospitales Universitarios Regional y Virgen de la Victoria. Málaga, España.

Instituto de Investigación Biomédica de Málaga. Málaga, España.

Cecilia Frecha, Consejo Superior de Investigaciones Cientificas y Técnicas

Consejo Superior de Investigaciones Cientificas y Técnicas. Argentina

Javier López, Clínica Colsanitas S.A

Laboratorio especializado de Clínica Colsanitas. Grupo INPAC. Clínica Colsanitas S.A. Bogotá, Colombia

David Carreño, Clínica Colsanitas S.A

Laboratorio especializado de Clínica Colsanitas. Grupo INPAC. Clínica Colsanitas S.A. Bogotá, Colombia

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Cómo citar

[1]
Perdomo, S. et al. 2020. La biopsia líquida en el diagnóstico y monitoreo de pacientes oncológicos: oportunidades y retos en Latinoamérica. Revista Colombiana de Cancerología. 24, 4 (nov. 2020), 164–77. DOI:https://doi.org/10.35509/01239015.44.

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30-11-2020

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