Carcinoma escamocelular cutáneo del tronco y las extremidades: utilidad del ganglio centinela en su estadificación

  • Daniel Fernando Contreras Pérez Hospital Pablo Tobón Uribe
  • Juan Pablo Molina Jiménez Fundación Universitaria Ciencias de la Salud
  • Sandra Esperanza Díaz Casas Instituto Nacional de Cancerología
Palabras clave: Carcinoma de células escamosas, Neoplasia de células escamosas, Neoplasias cutáneas, Biopsia del ganglio linfático centinela, Escisión del ganglio linfático, Ganglios linfáticos, Extremidades

Resumen

El carcinoma escamocelular (CEC) tiene un comportamiento biológico más agresivo cuando exhibe factores de riesgo. En este grupo, se comprometen los ganglios linfáticos hasta en 21% de los casos lo que disminuye la supervivencia a 5 años. El examen clínico de las cadenas ganglionares puede tener una tasa de falsos negativos cercana a 39%, determinando la necesidad de una herramienta que permita evaluar el compromiso ganglionar de un modo más preciso.
La biopsia del ganglio centinela ha sido documentada en la estadificación del CEC de cabeza y cuello, y el CEC de origen anogenital, pero en estas series de casos hay un escaso número de pacientes correspondientes a CEC cutáneo del tronco y las extremidades. El objetivo de esta revisión es describir las indicaciones y la plausibilidad de estadificar la extensión ganglionar usando la biopsia de ganglio centinela en pacientes con CEC cutáneo del tronco y extremidades.

Biografía del autor/a

Daniel Fernando Contreras Pérez, Hospital Pablo Tobón Uribe

Cirugía de Mama y Tumores de Tejidos Blandos, Hospital Pablo Tobón Uribe, Medellín, Colombia

Juan Pablo Molina Jiménez, Fundación Universitaria Ciencias de la Salud

Cirugía de Mama y Tumores de Tejidos Blandos, Fundación Universitaria Ciencias de la Salud, Bogotá D. C., Colombia

Sandra Esperanza Díaz Casas, Instituto Nacional de Cancerología

Cirugía de Mama y Tumores de Tejidos Blandos, Instituto Nacional de Cancerología, Bogotá D. C., Colombia

Referencias

Baykal C, Yazganoglu KD. Malignant Epithelial Tumors. En: Baykal C, Yazganoglu KD, editores. Clinical Atlas of Skin Tumors. Springer; 2014. p. 296-334.

https://doi.org/10.1007/978-3-642-40938-7_11

Bhambri SD, Scott. Bhambri, Avani Squamous Cell Carcinoma. En: Rigel DS, editores. Cancer of the Skin. Second edition ed. Elsevier Inc.; 2011. p. 124-39.

https://doi.org/10.1016/B978-1-4377-1788-4.00012-5

Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med. 2001;344:975-83.

https://doi.org/10.1056/NEJM200103293441306

Karia PS, Han J, Schmults CD. Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J Am Acad Dermatol. 2013;68:957-66.

https://doi.org/10.1016/j.jaad.2012.11.037

Brougham ND, Dennett ER, Cameron R, Tan ST. The incidence of metastasis from cutaneous squamous cell carcinoma and the impact of its risk factors. J Surg Oncol. 2012;106:811-5.

https://doi.org/10.1002/jso.23155

Brantsch KD, Meisner C, Schönfisch B, Trilling B, Wehner-Caroli J, Röcken M, et al. Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol. 2008;9:713-20.

https://doi.org/10.1016/S1470-2045(08)70178-5

Instituto Nacional de Cancerología. Anuario Estadístico 2012. Bogotá, 2015.

Schmitt AR, Brewer JD, Bordeaux JS, Baum CL. Staging for cutaneous squamous cell carcinoma as a predictor of sentinel lymph node biopsy results: meta-analysis of American Joint Committee on Cancer criteria and a proposed alternative system. JAMA Dermatol. 2014;150:19-24.

https://doi.org/10.1001/jamadermatol.2013.6675

Renzi C, Caggiati A, Mannooranparampil TJ, Passarelli F, Tartaglione G, Pennasilico GM, et al. Sentinel lymph node biopsy for high risk cutaneous squamous cell carcinoma: case series and review of the literature. Eur J Surg Oncol. 2007;33:364-9.

https://doi.org/10.1016/j.ejso.2006.10.017

Joseph MG, Zulueta WP, Kennedy PJ. Squamous cell carcinoma of the skin of the trunk and limbs: the incidence of metastases and their outcome. Aust N Z J Surg. 1992;62:697-701.

https://doi.org/10.1111/j.1445-2197.1992.tb07065.x

Weinberg AS, Ogle CA, Shim EK. Metastatic cutaneous squamous cell carcinoma: an update. Dermatol Surg. 2007;33: 885-99.

https://doi.org/10.1097/00042728-200708000-00001

Ross AS, Schmults CD. Sentinel lymph node biopsy in cutaneous squamous cell carcinoma: a systematic review of the English literature. Dermatol Surg. 2006;32:1309-21.

https://doi.org/10.1111/j.1524-4725.2006.32300.x

North JH, Spellman JE, Driscoll D, Velez A, Kraybill WG, Petrelli NJ. Advanced cutaneous squamous cell carcinoma of the trunk and extremity: analysis of prognostic factors. J Surg Oncol. 1997;64:212-7.

https://doi.org/10.1002/(SICI)1096-9098(199703)64:3<212::AID-JSO7>3.0.CO;2-D

Cherpelis BS, Marcusen C, Lang PG. Prognostic factors for metastasis in squamous cell carcinoma of the skin. Dermatol Surg. 2002;28:268-73.

https://doi.org/10.1046/j.1524-4725.2002.01169.x

Mullen JT, Feng L, Xing Y, Mansfield PF, Gershenwald JE, Lee JE, et al. Invasive squamous cell carcinoma of the skin: defining a high-risk group. Ann Surg Oncol. 2006;13:902-9.

https://doi.org/10.1245/ASO.2006.07.022

Schmults CD, Karia PS, Carter JB, Han J, Qureshi AA. Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study. JAMA Dermatol. 2013;149:541-7.

https://doi.org/10.1001/jamadermatol.2013.2139

Reule RB, Golda NJ, Wheeland RG. Treatment of cutaneous squamous cell carcinoma with perineural invasion using Mohs micrographic surgery: report of two cases and review of the literature. Dermatol Surg. 2009;35:1559-66.

https://doi.org/10.1111/j.1524-4725.2009.01276.x

Krediet JT, Beyer M, Lenz K, Ulrich C, Lange-Asschenfeldt B, Stockfleth E, et al. Sentinel lymph node biopsy and risk factors for predicting metastasis in cutaneous squamous cell carcinoma. Br J Dermatol. 2015;172:1029-36.

https://doi.org/10.1111/bjd.13508

Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL. Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis. JAMA Dermatol. 2016;152:419-28.

https://doi.org/10.1001/jamadermatol.2015.4994

(SIGN). SIGN. Management of primary cutaneous squamous cell carcinoma. Edinburgh: SIGN; 2014. June 2014 [(SIGN publication no. 140)]. Disponible en: http://www.sign.ac.uk/pdf/SIGN140.pdf

Rowe DE, Carroll RJ, Day CL. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol. 1992;26:976-90.

https://doi.org/10.1016/0190-9622(92)70144-5

Reschly MJ, Messina JL, Zaulyanov LL, Cruse W, Fenske NA. Utility of sentinel lymphadenectomy in the management of patients with high-risk cutaneous squamous cell carcinoma. Dermatol Surg. 2003;29:135-40.

https://doi.org/10.1046/j.1524-4725.2003.29035.x

Breuninger H, Schaumburg-Lever G, Holzschuh J, Horny HP. Desmoplastic squamous cell carcinoma of skin and vermilion surface: a highly malignant subtype of skin cancer. Cancer. 1997;79:915-9.

https://doi.org/10.1002/(SICI)1097-0142(19970301)79:5<915::AID-CNCR7>3.0.CO;2-A

NCCN. Squamous Cell Skin Cancer (Guideline Version 1.2016) Disponible en: https://www.nccn.org/professionals/physician_gls/pdf/squamous.pdf

García O, Díaz S, Vergara E, Duarte C, Ángel J, Villamizar L, et al. Sentinel Node in Cutaneous Malignant Melanoma in the Trunk and Extremities: Experience at the National Cancer Institute, Bogotá, Colombia, 2000-2007. Rev Colomb Cancerol. 2011;15:119-26.

https://doi.org/10.1016/S0123-9015(11)70060-9

Michl C, Starz H, Bachter D, Balda BR. Sentinel lymphonodectomy in nonmelanoma skin malignancies. Br J Dermatol. 2003;149:763-9.

https://doi.org/10.1046/j.1365-2133.2003.05578.x

Lane JE, Kent DE. Surgical margins in the treatment of nonmelanoma skin cancer and mohs micrographic surgery. Curr Surg. 2005;62:518-26.

https://doi.org/10.1016/j.cursur.2005.01.003

Lansbury L, Bath-Hextall F, Perkins W, Stanton W, Leonardi-Bee J. Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies. BMJ. 2013;347:f6153.

https://doi.org/10.1136/bmj.f6153

Brodland DG, Zitelli JA. Surgical margins for excision of primary cutaneous squamous cell carcinoma. J Am Acad Dermatol. 1992;27:241-8.

https://doi.org/10.1016/0190-9622(92)70178-I

Palyca P, Koshenkov VP, Mehnert JM. Developments in the treatment of locally advanced and metastatic squamous cell carcinoma of the skin: a rising unmet need. Am Soc Clin Oncol Educ Book. 2014:e397-404.

https://doi.org/10.14694/EdBook_AM.2014.34.e397

Farasat S, Yu SS, Neel VA, Nehal KS, Lardaro T, Mihm MC, et al. A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics. J Am Acad Dermatol.2011;64:1051-9.

https://doi.org/10.1016/j.jaad.2010.08.033

Knappe M, Louw M, Gregor RT. Ultrasonography-guided fine needle aspiration for the assessment of cervical metastases. Arch Otolaryngol Head Neck Surg. 2000;126:1091-6.

https://doi.org/10.1001/archotol.126.9.1091

Land R, Herod J, Moskovic E, King M, Sohaib SA, Trott P, et al. Routine computerized tomography scanning, groin ultrasound with or without fine needle aspiration cytology in the surgical management of primary squamous cell carcinoma of the vulva. Int J Gynecol Cancer. 2006;16:312-7.

https://doi.org/10.1111/j.1525-1438.2006.00340.x

Salguero-Fernández I, Rios-Buceta L, Jaén-Olasolo P. [Sentinel lymph node in nonmelanoma skin cancer]. Actas Dermosifiliogr. 2011;102:589-98.

https://doi.org/10.1016/j.ad.2011.05.010

Morton DL, Thompson JF, Essner R, Elashoff R, Stern SL, Nieweg OE, et al. Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: a multicenter trial. Multicenter Selective Lymphadenectomy Trial Group. Ann Surg. 1999;230: 453-63.

https://doi.org/10.1097/00000658-199910000-00001

Gershenwald JE, Thompson W, Mansfield PF, Lee JE, Colome MI, Tseng CH, et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol. 1999;17:976-83.

https://doi.org/10.1200/JCO.1999.17.3.976

Krag D, Weaver D, Ashikaga T, Moffat F, Klimberg VS, Shriver C, et al. The sentinel node in breast cancer-a multicenter validation study. N Engl J Med. 1998;339:941-6.

https://doi.org/10.1056/NEJM199810013391401

McMasters KM, Tuttle TM, Carlson DJ, Brown CM, Noyes RD, Glaser RL, et al. Sentinel lymph node biopsy for breast cancer: a suitable alternative to routine axillary dissection in multi institutional practice when optimal technique is used. J Clin Oncol. 2000;18:2560-6.

https://doi.org/10.1200/JCO.2000.18.13.2560

McMasters KM, Noyes RD, Reintgen DS, Goydos JS, Beitsch PD, Davidson BS, et al. Lessons learned from the Sunbelt Melanoma Trial. J Surg Oncol. 2004;86:212-23.

https://doi.org/10.1002/jso.20084

Berk DR, Johnson DL, Uzieblo A, Kiernan M, Swetter SM. Sentinel lymph node biopsy for cutaneous melanoma: the Stanford experience, 1997-2004. Arch Dermatol. 2005;141:1016-22.

https://doi.org/10.1001/archderm.141.8.1016

Morton DL, Thompson JF, Cochran AJ, Mozzillo N, Elashoff R, Essner R, et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med. 2006;355:1307-17.

https://doi.org/10.1056/NEJMoa060992

Johnson TM, Sondak VK, Bichakjian CK, Sabel MS. The role of sentinel lymph node biopsy for melanoma: evidence assessment. J Am Acad Dermatol. 2006;54:19-27.

https://doi.org/10.1016/j.jaad.2005.09.029

Wagner JD, Evdokimow DZ, Weisberger E, Moore D, Chuang TY, Wenck S, et al. Sentinel node biopsy for high-risk nonmelanoma cutaneous malignancy. Arch Dermatol. 2004;140:75-9.

https://doi.org/10.1001/archderm.140.1.75

Altinyollar H, Berbero˘glu U, Celen O. Lymphatic mapping and sentinel lymph node biopsy in squamous cell carcinoma of the lower lip. Eur J Surg Oncol. 2002;28:72-4.

https://doi.org/10.1053/ejso.2001.1206

Nouri K, Rivas MP, Pedroso F, Bhatia R, Civantos F. Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck. Arch Dermatol. 2004;140:1284.

https://doi.org/10.1001/archderm.140.10.1284-a

Eastman AL, Erdman WA, Lindberg GM, Hunt JL, Purdue GF, Fleming JB. Sentinel lymph node biopsy identifies occult nodal metastases in patients with Marjolin's ulcer. J Burn Care Rehabil. 2004;25:241-5.

https://doi.org/10.1097/01.BCR.0000124791.17426.58

Ali S, Tiwari RM, Snow GB. False-positive and false-negative neck nodes. Head Neck Surg. 1985;8:78-82.

https://doi.org/10.1002/hed.2890080204

Sloan P. Head and neck sentinel lymph node biopsy: current state of the art. Head Neck Pathol. 2009;3:231-7.

https://doi.org/10.1007/s12105-009-0132-3

Ozc¸elik D, Tatlidede S, Hacikerim S, U˘gurlu K, Atay M. The use of sentinel lymph node biopsy in squamous cell carcinoma of the foot: a case report. J Foot Ankle Surg. 2004;43:60-3.

https://doi.org/10.1053/j.jfas.2003.11.003

Hatta N, Morita R, Yamada M, Takehara K, Ichiyanagi K, Yokoyama K. Implications of popliteal lymph node detected by sentinel lymph node biopsy. Dermatol Surg. 2005;31:327-30.

https://doi.org/10.1097/00042728-200503000-00014

Cuccia G, Colonna MR, Papalia I, Manasseri B, Romeo M, d'Alcontres FS. The use of sentinel node biopsy and selective lymphadenectomy in squamous cell carcinoma of the upper limb. Usefulness of sentinel node biopsy to avoid useless lymphadenectomies in high-risk upper limb SCC. Ann Ital Chir. 2008;79:67-71.

Liu YY, Rozen WM, Rahdon R. Sentinel lymph node biopsy for squamous cell carcinoma of the extremities: case report and review of the literature. Anticancer Res. 2011;31:1443-6.

Stadelmann WK, Javaheri S, Cruse CW, Reintgen DS. The use of selective lymphadenectomy in squamous cell carcinoma of the wrist: a case report. J Hand Surg Am. 1997;22:726-31.

https://doi.org/10.1016/S0363-5023(97)80136-0

Yamada M, Hatta N, Sogo K, Komura K, Hamaguchi Y, Takehara K. Management of squamous cell carcinoma in a patient with recessive-type epidermolysis bullosa dystrophica. Dermatol Surg. 2004;30:1424-9.

https://doi.org/10.1111/j.1524-4725.2004.30440.x

Perez-Naranjo L, Herrera-Saval A, Garcia-Bravo B, Perez-Bernal AM, Camacho F. Sentinel lymph node biopsy in recessive dystrophic epidermolysis bullosa and squamous cell carcinoma. Arch Dermatol. 2005;141:110-1.

https://doi.org/10.1001/archderm.141.1.110

Sahn RE, Lang PG. Sentinel lymph node biopsy for high-risk nonmelanoma skin cancers. Dermatol Surg. 2007;33:786-92.

https://doi.org/10.1097/00042728-200707000-00002

Fujiwara M, Mizukami T, Suzuki A, Fukamizu H. Sentinel lymph node detection in skin cancer patients using real-time fluorescence navigation with indocyanine green: preliminary experience. J Plast Reconstr Aesthet Surg. 2009;62:e373-8.

https://doi.org/10.1016/j.bjps.2007.12.074

Kwon S, Dong ZM, Wu PC. Sentinel lymph node biopsy for highrisk cutaneous squamous cell carcinoma: clinical experience and review of literature. World J Surg Oncol. 2011;9:80.

https://doi.org/10.1186/1477-7819-9-80

Jambusaria-Pahlajani A, Kanetsky PA, Karia PS, Hwang WT, Gelfand JM, Whalen FM, et al. Evaluation of AJCC tumor staging for cutaneous squamous cell carcinoma and a proposed alternative tumor staging system. JAMA Dermatol. 2013;149:402-10.

https://doi.org/10.1001/jamadermatol.2013.2456

Veness MJ, Palme CE, Morgan GJ. High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease. Cancer. 2006;106:2389-96.

https://doi.org/10.1002/cncr.21898

Terada KY, Shimizu DM, Wong JH. Sentinel node dissection and ultrastaging in squamous cell cancer of the vulva. Gynecol Oncol. 2000;76:40-4.

https://doi.org/10.1006/gyno.1999.5660

Diaz S, Molina J, Contreras D, Lopez D, Garcia O, García M, et al. Sentinel node in squamous cell carcinoma of the skin at the trunk and extremities: Experience in a Latin American reference center. Publishing process.

Publicado
2018-03-01
Sección
Artículos de revisión